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Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil

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dc.contributor.authorPinheiro, Tauyne Menegaldo
dc.contributor.authorOliveira Mota, Manlio Tasso de
dc.contributor.authorAranha Watanabe, Aripuana Sakurada
dc.contributor.authorBiselli-Perico, Joice Matos [UNESP]
dc.contributor.authorDrumond, Betania Paiva
dc.contributor.authorRibeiro, Milene Rocha
dc.contributor.authorVedovello, Danila
dc.contributor.authorAraujo, Joao Pessoa [UNESP]
dc.contributor.authorPaolucci Pimenta, Paulo Filemon
dc.contributor.authorChaves, Barbara Aparecida
dc.contributor.authorCarneiro da Silva, Mayara Marques
dc.contributor.authorAndrade Batista, Izabella Cristina
dc.contributor.authorPapa, Michelle Premazzi
dc.contributor.authorMeuren, Lana Monteiro
dc.contributor.authorOliveira Lucas, Carolina Goncalves de
dc.contributor.authorMatassoli, Flavio Lemos
dc.contributor.authorVega Gonzales Gil, Laura Helena
dc.contributor.authorBozzi, Adriana
dc.contributor.authorCalzavara-Silva, Carlos Eduardo
dc.contributor.authorArruda, Luciana Barros de
dc.contributor.authorSouza, Danielle da Gloria de
dc.contributor.authorTeixeira, Mauro Martins
dc.contributor.authorVasilakis, Nikos
dc.contributor.authorNogueira, Mauricio Lacerda
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFiocruz MS
dc.contributor.institutionUniv Estado Amazonas
dc.contributor.institutionFundacao Med Trop Dr Heitor Vieira Dourado FMT HV
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniv Texas Med Branch
dc.contributor.institutionUniv Fed Juiz de Fora
dc.date.accessioned2018-11-26T17:51:56Z
dc.date.available2018-11-26T17:51:56Z
dc.date.issued2018-05-01
dc.description.abstractThe dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In Sao Jose do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in Sao Jose do Rio Preto.en
dc.description.affiliationFac Med Sao Jose do Rio Preto, Lab Pesquisa Virol, Dept Doencas Dermatol Infecciosas & Parasitarias, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Lab Virus, Inst Ciencias Biol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Estadual Paulista Julio de Mesquita, Inst Biociencias, Lab Virol, Dept Microbiol & Imunol, Botucatu, SP, Brazil
dc.description.affiliationFiocruz MS, Ctr Pesquisas Rene Rachou, Lab Entomol Med, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Estado Amazonas, Programa Posgrad Med Trop, Manaus, AM, Brazil
dc.description.affiliationFundacao Med Trop Dr Heitor Vieira Dourado FMT HV, Manaus, AM, Brazil
dc.description.affiliationFiocruz MS, Dept Virol, Ctr Pesquisas Aggeu Magalhaes, Recife, PE, Brazil
dc.description.affiliationFiocruz MS, Ctr Pesquisas Rene Rachou, Lab Imunol Celular & Mol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Microbiol Prof Paulo de Goes, Dept Virol, Lab Genet & Imunol Infeccoes Virais, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Microbiol, Inst Ciencias Biol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Bioquim & Imunol, Inst Ciencias Biol, Lab Imunofarmacol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Texas Med Branch, Ctr Trop Dis, Inst Human Infect & Immun, Dept Pathol,Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA
dc.description.affiliationUniv Fed Juiz de Fora, Lab Virol, Dept Parasitol Microbiol & Imunol, Juiz De Fora, MG, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Biol, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio de Mesquita, Inst Biociencias, Lab Virol, Dept Microbiol & Imunol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Biol, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipNIH/NIAID
dc.description.sponsorshipIdFAPESP: 2012/11733-6
dc.description.sponsorshipIdFAPESP: 2013/21719-3
dc.description.sponsorshipIdFAPESP: 2015/22750-7
dc.description.sponsorshipIdNIH/NIAID: U01 AI115577
dc.format.extent25
dc.identifierhttp://dx.doi.org/10.1371/journal.pntd.0006525
dc.identifier.citationPlos Neglected Tropical Diseases. San Francisco: Public Library Science, v. 12, n. 5, 25 p., 2018.
dc.identifier.doi10.1371/journal.pntd.0006525
dc.identifier.fileWOS000434021900060.pdf
dc.identifier.issn1935-2735
dc.identifier.urihttp://hdl.handle.net/11449/164271
dc.identifier.wosWOS:000434021900060
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos Neglected Tropical Diseases
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleViral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazilen
dc.typeArtigo
dcterms.rightsHolderPublic Library Science
dspace.entity.typePublication
unesp.author.orcid0000-0001-8585-8206[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentMicrobiologia e Imunologia - IBBpt
unesp.departmentBiologia - IBILCEpt

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Botucatu - IBB - Instituto de Biociências
São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas