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Cytotoxic Guanidine Alkaloids from Pterogyne nitens

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dc.contributor.authorRegasini, Luis Octavio [UNESP]
dc.contributor.authorCastro-Gamboa, Ian [UNESP]
dc.contributor.authorSiqueira Silva, Dulce Helena [UNESP]
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.authorBarreiro, Eliezer Jesus
dc.contributor.authorPinheiro Ferreira, Paulo Michel
dc.contributor.authorPessoa, Claudia
dc.contributor.authorCosta Lotufo, Leticia Veras
dc.contributor.authorMoraes, Manoel Odorico de
dc.contributor.authorMarx Young, Maria Claudia
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal do Ceará (UFC)
dc.contributor.institutionInst Bot
dc.date.accessioned2014-05-20T14:20:11Z
dc.date.available2014-05-20T14:20:11Z
dc.date.issued2009-03-01
dc.description.abstractAs part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of I and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells.en
dc.description.affiliationSão Paulo State Univ, Inst Chem, Nucley Bioassay Biosynth & Ecophys Nat Prod, UNESP, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, LASSBio, Ctr Ciencias Saude, Fac Farm, BR-21944910 Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal do Ceará (UFC), LOE, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, Ceara, Brazil
dc.description.affiliationInst Bot, BR-01061970 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Inst Chem, Nucley Bioassay Biosynth & Ecophys Nat Prod, UNESP, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 03/02176-7
dc.format.extent473-476
dc.identifierhttp://dx.doi.org/10.1021/np800612x
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 72, n. 3, p. 473-476, 2009.
dc.identifier.doi10.1021/np800612x
dc.identifier.issn0163-3864
dc.identifier.lattes4702004904231248
dc.identifier.lattes1308042794786872
dc.identifier.lattes4484083685251673
dc.identifier.urihttp://hdl.handle.net/11449/26062
dc.identifier.wosWOS:000264627600025
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleCytotoxic Guanidine Alkaloids from Pterogyne nitensen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/page/policy/nih/index.html
dcterms.rightsHolderAmer Chemical Soc
dspace.entity.typePublication
unesp.author.lattes4702004904231248
unesp.author.lattes1308042794786872
unesp.author.lattes4484083685251673
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

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Araraquara - IQAR - Instituto de Química