Effects of acetylsalicylic acid and acetic acid solutions in VX2 carcinoma cells. In vitro analysis
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Purpose: To analyze, in vitro, the effects of acetylsalicylic acid (aspirin) and acetic acid solutions on VX2 carcinoma cells in suspension and to examine the correlation between these effects and neoplastic cell death. Methods: The VX2 tumor cells (107 cells/ml) were incubated in solutions containing differing concentrations (2.5% and 5%) of either acetylsalicylic acid or acetic acid, or in saline solution (controls). Every five minutes, cell viability was tested (using the trypan blue test) and analyzed under light microscopy. Results: Tumor cell viability (in %) decreased progressively and, by 30 minutes, neoplastic cell death had occurred in all solutions. Conclusion: Based on this experimental model and the methodology employed, we conclude that these solutions cause neoplastic cell death in vitro.
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Acetic acid , Aspirin , Carcinoma , In vitro , acetic acid , acetylsalicylic acid , bicarbonate , sodium chloride , trypan blue , animal cell , carcinoma cell , cell death , cell suspension , cell viability , controlled study , correlation analysis , drug blood level , in vitro study , incubation time , microscopy , nonhuman , Acetic Acid , Animals , Cell Death , Cell Survival , Drug Combinations , Drug Screening Assays, Antitumor , Indicators and Reagents , Microscopy, Fluorescence , Neoplasms, Experimental , Rabbits
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Acta Cirurgica Brasileira, v. 21, n. 3, p. 151-154, 2006.
