Effects of acetylsalicylic acid and acetic acid solutions in VX2 carcinoma cells. In vitro analysis
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Purpose: To analyze, in vitro, the effects of acetylsalicylic acid (aspirin) and acetic acid solutions on VX2 carcinoma cells in suspension and to examine the correlation between these effects and neoplastic cell death. Methods: The VX2 tumor cells (107 cells/ml) were incubated in solutions containing differing concentrations (2.5% and 5%) of either acetylsalicylic acid or acetic acid, or in saline solution (controls). Every five minutes, cell viability was tested (using the trypan blue test) and analyzed under light microscopy. Results: Tumor cell viability (in %) decreased progressively and, by 30 minutes, neoplastic cell death had occurred in all solutions. Conclusion: Based on this experimental model and the methodology employed, we conclude that these solutions cause neoplastic cell death in vitro.
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Acetic acid Aspirin Carcinoma In vitro acetic acid acetylsalicylic acid bicarbonate sodium chloride trypan blue animal cell carcinoma cell cell death cell suspension cell viability controlled study correlation analysis drug blood level in vitro study incubation time microscopy nonhuman Acetic Acid Animals Cell Death Cell Survival Drug Combinations Drug Screening Assays, Antitumor Indicators and Reagents Microscopy, Fluorescence Neoplasms, Experimental Rabbits
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Acta Cirurgica Brasileira, v. 21, n. 3, p. 151-154, 2006.
