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Antarctic environments as a source of bacterial and fungal therapeutic enzymes

dc.contributor.authorLima, Igor G. O.
dc.contributor.authorBispo, James R. S.
dc.contributor.authorAgostinho, Adson Y. H.
dc.contributor.authorDe Queiroz, Aline C.
dc.contributor.authorMoreira, Magna Suzana A.
dc.contributor.authorPassarini, Michel Rodrigo Z.
dc.contributor.authorDe Oliveira, Valéria M.
dc.contributor.authorSette, Lara D. [UNESP]
dc.contributor.authorRosa, Luiz Henrique
dc.contributor.authorDuarte, Alysson Wagner F.
dc.contributor.institutionComplexo de Ciências Médicas e Enfermagem
dc.contributor.institutionInstituto de Ciências Biológicas e da Saúde
dc.contributor.institutionUniversidade Federal da Integração Latino-Americana
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2022-04-28T19:50:50Z
dc.date.available2022-04-28T19:50:50Z
dc.date.issued2022-01-01
dc.description.abstractMicrobial therapeutic enzymes are the protagonists in the pharmacological treatment of different human diseases. The intrinsic enzymatic characteristics, such as high affinity and specificity to the corresponding substrate, enable effective therapies, with minimal adverse effects and complete remission. However, immunogenicity, short half-life, low enzymatic yield, and low selectivity regarding available enzyme drugs are currently the main obstacles to their development and the broad adherence to therapeutic protocols. By harboring adapted and still unexplored microbial life, environments of extreme conditions, such as Antarctica, become especially important in the prospecting and development of new enzymatic compounds that present higher yields and the possibility of genetic improvement. Antarctic microorganisms have adaptation mechanisms, such as more fluid cell membranes, production of antifreeze proteins and enzymes with more malleable structures, more robust, stable, selective catalytic sites for their respective substrates, and high antioxidant capacity. In this context, this review aims to explore enzymes synthesized by bacteria and fungi from Antarctica as potential drug producers, capable of providing therapeutic efficacy, less adverse effects, and lower production costs with highlight to L-Asparaginase, collagenase, superoxide dismutase and ribonucleases. In addition, this review highlights the unique biotechnological profile of these Antarctic extremophile microorganisms.en
dc.description.affiliationUniversidade Federal de Alagoas Complexo de Ciências Médicas e Enfermagem, Campus Arapiraca, Av. Manoel Severino Barbosa, s/n, Bom Sucesso
dc.description.affiliationUniversidade Federal de Alagoas Instituto de Ciências Biológicas e da Saúde, Av. Lourival Melo Mota, s/n, Tabuleiro do Martins
dc.description.affiliationUniversidade Federal da Integração Latino-Americana, Av. Silvio Américo Sasdelli, 1842, Itaipú A
dc.description.affiliationUniversidade Estadual de Campinas Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrárias, R. Alexandre Cazellato, 999, Betel
dc.description.affiliationDepartamento de Biologia Geral e Aplicada Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho, Av. 24 A, 1515, Bela Vista
dc.description.affiliationUniversidade Federal de Minas Gerais Instituto de Ciências Biológicas, Av. Presidente Antônio Carlos, 6627, Pampulha
dc.description.affiliationUnespDepartamento de Biologia Geral e Aplicada Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho, Av. 24 A, 1515, Bela Vista
dc.identifierhttp://dx.doi.org/10.1590/0001-3765202220210452
dc.identifier.citationAnais da Academia Brasileira de Ciencias, v. 94.
dc.identifier.doi10.1590/0001-3765202220210452
dc.identifier.issn1678-2690
dc.identifier.issn0001-3765
dc.identifier.scopus2-s2.0-85124679950
dc.identifier.urihttp://hdl.handle.net/11449/223471
dc.language.isoeng
dc.relation.ispartofAnais da Academia Brasileira de Ciencias
dc.sourceScopus
dc.subjectAntarctica
dc.subjectCollagenase
dc.subjectExtremophiles
dc.subjectL-Asparaginase
dc.subjectSuperoxide dismutase
dc.subjectTherapeutics enzymes
dc.titleAntarctic environments as a source of bacterial and fungal therapeutic enzymesen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0002-0021-7985[1]
unesp.author.orcid0000-0001-6074-4464[2]
unesp.author.orcid0000-0001-7559-2539[3]
unesp.author.orcid0000-0002-6362-2726[4]
unesp.author.orcid0000-0002-9979-1994[5]
unesp.author.orcid0000-0002-8614-1896[6]
unesp.author.orcid0000-0001-8817-4758[7]
unesp.author.orcid0000-0002-5980-3786[8]
unesp.author.orcid0000-0001-9749-5182[9]
unesp.author.orcid0000-0001-9626-7524[10]

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