Publicação: Dendritic cell vaccines for cancer therapy: Fundamentals and clinical trials
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Capítulo de livro
Direito de acesso
Acesso restrito
Resumo
One of the main challenges in antitumor immunotherapy is the low immunogenicity of tumor cells and the tolerogenic tumor microenvironment. The central role of dendritic cells (DCs), and the demonstration that ex vivo exposure of DC to tumor antigens was able to restore a specific T response, instigated the development of antitumor DC-based therapeutic vaccines. Several clinical trials have shown that DC vaccines are able to improve such clinical follow-up parameters as the decrease of serum tumor markers, disease stabilization, reduced disease relapse, low collateral effects, reduced death risk, and even tumor regression. However, the technical conditions for achieving vaccine efficacy is still not completely understood, since published protocols vary widely on precursor cell sources, differentiation and maturation conditions, antigen sources and loading methods, as well as administration routes. Despite these limitations, promising results stimulate the search for the best ways to improve tumor immunogenicity, DC antigen-presenting function, responsiveness of effector cells in the tumor microenvironment, as well as overcoming the tolerogenic or suppressive status of the patient‘s immune system.
Descrição
Palavras-chave
Idioma
Inglês
Como citar
Cancer Immunology: Bench to Bedside Immunotherapy of Cancers, p. 359-373.
