Pressure evaluation of the antireflux ability of the rat ureterovesical junction

The bladder pressure necessary to cause vesicoureteral reflux (VUR) was measured in 16 female rats. Under general anesthesia, the ureters were exposed via an abdominal incission and a pressure catheter was placed near the uterovesical junction. Values of bladder distension and bladder pressure increase to cause VUR were obtained by injecting isotonic saline in one ureter until VUR in the opposite ureter was detected as a sudden pressure increase. After 5 min the same procedure was done on the contralateral side. This procedure was repeated eight times in each rat with a 15-min intermission. The bladder pressure at which VUR occurred was measured through a uretral catheter. Two groups were studied: G1, control, and G2, administration of intravenous metoclopramide (0.007 mg/100 g body weight) four times.

Keywords

metoclopramide, animal experiment, bladder, bladder distension, bladder pressure, diagnosis, drug efficacy, intravenous drug administration, micturition, nonhuman, priority journal, rat, ureter, ureterovesical junction, urinary tract, vesicoureteral reflux, Animal, Bladder, Comparative Study, Evaluation Studies, Female, Metoclopramide, Pressure, Rats, Rats, Inbred Strains, Support, Non-U.S. Gov't, Ureter, Urodynamics, Vesico-Ureteral Reflux