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Evaluation of blood compatibility of plasma deposited heparin-like films and SF6 plasma treated surfaces

dc.contributor.authorPerrenoud, Ivanira Antunes [UNESP]
dc.contributor.authorRangel, Elidiane Cipriano [UNESP]
dc.contributor.authorMota, Rogério Pinto [UNESP]
dc.contributor.authorDurrant, Steven Frederick [UNESP]
dc.contributor.authorDa Cruz, Nilson Cristino [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:24:36Z
dc.date.available2014-05-27T11:24:36Z
dc.date.issued2010-01-01
dc.description.abstractIn devices used in open-heart surgery and dialysis, blood must be continuously processed using extracorporeal circuits composed of peristaltic pumps and active components such as specifc flters and oxygenators. Several procedures have been employed to avoid blood coagulation induced by contact with the artifcial surfaces of such devices. Often heparin, a bioactive protein able to prevent clot formation, is employed. In this work, we have used heparin-containing gas plasmas to evaluate the possibility of depositing adherent anticoagulant flms onto PVC and glass surfaces. The flms were produced by radiofrequency plasma enhanced chemical vapor deposition from heparin/isopropanol and heparin/hexamethyldisiloxane solutions. In addition, the effects of exposure to SF6 plasmas on the compatibility of such surfaces have also been investigated. The blood compatibility was evaluated through the determination of the density of platelets and fbrinogen and activated partial thromboplastin (APTT) and prothrombin times (PT) of human blood freshly collected and after contact for 2.5 hours with different surfaces. The deposited flms were also characterized by infrared spectroscopy, contact angle and surface energy measurements. The coagulation time of blood, placed in contact with glass substrates coated by PECVD flms of heparin/isopropanol mixtures, and in contact with SF6 plasma-treated PVC, increased by about 60 and 20%, respectively, compared to the values measured with untreated samples.en
dc.description.affiliationFaculdade de Engenharia São Paulo State University - UNESP Campus de Guaratinguetá, Guaratinguetá - SP
dc.description.affiliationLaboratório de Plasmas Tecnológicos São Paulo State University - UNESP Campus Experimental de Sorocaba, Avenida Três de Março, 511, 18087-180 Sorocaba - SP
dc.description.affiliationUnespFaculdade de Engenharia São Paulo State University - UNESP Campus de Guaratinguetá, Guaratinguetá - SP
dc.description.affiliationUnespLaboratório de Plasmas Tecnológicos São Paulo State University - UNESP Campus Experimental de Sorocaba, Avenida Três de Março, 511, 18087-180 Sorocaba - SP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent95-98
dc.identifierhttp://dx.doi.org/10.1590/S1516-14392010000100019
dc.identifier.citationMaterials Research, v. 13, n. 1, p. 95-98, 2010.
dc.identifier.doi10.1590/S1516-14392010000100019
dc.identifier.file2-s2.0-77952677946.pdf
dc.identifier.issn1516-1439
dc.identifier.orcid0000-0002-4511-3768
dc.identifier.scieloS1516-14392010000100019
dc.identifier.scopus2-s2.0-77952677946
dc.identifier.urihttp://hdl.handle.net/11449/71530
dc.identifier.wosWOS:000276894200019
dc.language.isoeng
dc.relation.ispartofMaterials Research
dc.relation.ispartofjcr1.103
dc.relation.ispartofsjr0,398
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBiomaterials
dc.subjectBlood compatibility
dc.subjectHeparin
dc.subjectPECVD
dc.subjectPlasma treatment
dc.subjectActive components
dc.subjectBioactive proteins
dc.subjectBlood coagulation
dc.subjectClot formation
dc.subjectCoagulation time
dc.subjectGas plasma
dc.subjectGlass substrates
dc.subjectGlass surfaces
dc.subjectHuman bloods
dc.subjectOpen-heart surgery
dc.subjectPeristaltic pump
dc.subjectRadio-frequency plasma enhanced chemical vapor deposition
dc.subjectSurface energy measurements
dc.subjectBiological materials
dc.subjectBlood substitutes
dc.subjectCoagulation
dc.subjectContact angle
dc.subjectDialysis
dc.subjectGlass
dc.subjectInfrared spectroscopy
dc.subjectOxygenators
dc.subjectPlasma deposition
dc.subjectPlasma enhanced chemical vapor deposition
dc.subjectPlasmas
dc.subjectPolysaccharides
dc.subjectPolyvinyl chlorides
dc.subjectSubstrates
dc.subjectSurface chemistry
dc.subjectSurface tension
dc.subjectBlood
dc.titleEvaluation of blood compatibility of plasma deposited heparin-like films and SF6 plasma treated surfacesen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/mr/iaboutj.htm
dspace.entity.typePublication
unesp.author.orcid0000-0002-4511-3768[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, Sorocabapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Engenharia, Guaratinguetápt
unesp.departmentFísica e Química - FEGpt
unesp.departmentEngenharia de Controle e Automação - ICTSpt

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