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Publicação:
Interação entre Hb B2 e Hb S

dc.contributor.authorFerreira, Natália [UNESP]
dc.contributor.authorZamaro, Paula J. A. [UNESP]
dc.contributor.authorBonini-Domingos, Claudia R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T21:01:18Z
dc.date.available2022-04-28T21:01:18Z
dc.date.issued2010-02-01
dc.description.abstractHemoglobinopathies and thalassemias are the most common genetic diseases, and in most cases, present as heterozygous. Due to the diversity of hemoglobin variants, specific and complementary methodologies are necessary for a precise laboratorial diagnosis, able to elucidate possible interactions between genetic polymorphisms. This case report describes an interaction between hemoglobin B2 and hemoglobin S in a Caucasian woman from the southeastern region of Brazil. This interaction was identified by electrophoresis in different pHs, high performance liquid chromatography and PCR-RFLP. As hemoglobin B2 is eluted in the same window as hemoglobin S in automatic HPLC systems and is hardly seen in alkaline electrophoresis due to its low concentration, the association must be confirmed using additional laboratorial tests, including molecular biology techniques. These tests should be included in the routine practice of hemoglobinopathy diagnosis in order to correctly identify hemoglobin variants and to know the real frequency of these mutations in the Brazilian population.en
dc.description.affiliationUnesp Ibilce Laboratório de Hemoglobinas e Genética das Doenças Hematológicas (LHGDH)
dc.description.affiliationLHGDH Unesp, São José do Rio Preto-SP
dc.description.affiliationUnespUnesp Ibilce Laboratório de Hemoglobinas e Genética das Doenças Hematológicas (LHGDH)
dc.description.affiliationUnespLHGDH Unesp, São José do Rio Preto-SP
dc.identifier.citationRevista Brasileira de Hematologia e Hemoterapia, v. 32, n. 1, 2010.
dc.identifier.issn1516-8484
dc.identifier.scopus2-s2.0-77952648479
dc.identifier.urihttp://hdl.handle.net/11449/225846
dc.language.isopor
dc.relation.ispartofRevista Brasileira de Hematologia e Hemoterapia
dc.sourceScopus
dc.subjectAbnormal hemoglobin
dc.subjectDiagnosis
dc.subjectHemoglobinopathies
dc.titleInteração entre Hb B2 e Hb Spt
dc.title.alternativeInteraction between Hb B2 and Hb Sen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia - IBILCEpt

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