Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
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Federacao Brasileira Soc Ginecologia & Obstetricia-febrasgo
Federação das Associações de Ginecologia e Obstetrícia
Federação das Associações de Ginecologia e Obstetrícia
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Objective We examined the interaction of polymorphisms in the genes heme oxygenase-1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. Methods The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA), and the levels of enzyme heme oxygenase-1 (HO-1) were measured using enzyme-linked immunosorbent assay (ELISA). Results We found interactions between genotypes of the HMOX-1 and NOS3 genes and responsiveness tomethyldopa and that PE genotyped as AT presents lower levels of protein HO-1 compared with AA. Conclusion We found interactions between the HMOX-1 and NOS3 genes and responsiveness to methyldopa and that the HMOX1 polymorphism affects the levels of enzyme HO-1 in responsiveness to methyldopa and to total antihypertensive therapy. These data suggest impact of the combination of these two polymorphisms on antihypertensive responsiveness in PE.
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Revista Brasileira De Ginecologia E Obstetricia. Rio De Janeiro Rj: Federacao Brasileira Soc Ginecologia & Obstetricia-febrasgo, v. 42, n. 8, p. 460-467, 2020.
