Publicação:
A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles

dc.contributor.authorCabrera, Flavio C. [UNESP]
dc.contributor.authorMelo, Antonio F. A. A.
dc.contributor.authorSouza, Joao C. P. de
dc.contributor.authorJob, Aldo E. [UNESP]
dc.contributor.authorCrespilho, Frank N.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-10-21T20:50:22Z
dc.date.available2015-10-21T20:50:22Z
dc.date.issued2015-01-01
dc.description.abstractMagnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (phi = 10 nm) decorated with AuNPs (phi = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications.en
dc.description.affiliationUNESP, FCT, Dept Fis Quim &Biol, Presidente Prudente, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Quim, Sao Carlos, SP, Brazil
dc.description.affiliationUnespUNESP, FCT, Dept Fis Quim &Biol, Presidente Prudente, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipBrazilian agency INEO
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2013/14262-7
dc.description.sponsorshipIdFAPESP: 2013/04663-4
dc.description.sponsorshipIdCNPq: 306106/2013-2
dc.description.sponsorshipIdCNPq: 478525/2013-3
dc.description.sponsorshipIdFAPESP: 2011/23362-0
dc.format.extent1835-1841
dc.identifierhttp://pubs.rsc.org/en/Content/ArticleLanding/2015/LC/C4LC01483A#!divAbstract
dc.identifier.citationLab On A Chip, v. 15, n. 8, p. 1835-1841, 2015.
dc.identifier.doi10.1039/c4lc01483a
dc.identifier.issn1473-0197
dc.identifier.urihttp://hdl.handle.net/11449/129322
dc.identifier.wosWOS:000352088400005
dc.language.isoeng
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofLab On A Chip
dc.relation.ispartofjcr5.995
dc.relation.ispartofsjr2,158
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleA flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticlesen
dc.typeArtigo
dcterms.rightsHolderRoyal Soc Chemistry
dspace.entity.typePublication
unesp.author.lattes6475585105456744[4]
unesp.author.orcid0000-0002-1979-8257[4]
unesp.author.orcid0000-0001-9962-3889[3]
unesp.author.orcid0000-0003-4830-652X[5]
unesp.author.orcid0000-0001-7924-7089[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências e Tecnologia, Presidente Prudentept
unesp.departmentFísica, Química e Biologia - FCTpt

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