Publicação: A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles
dc.contributor.author | Cabrera, Flavio C. [UNESP] | |
dc.contributor.author | Melo, Antonio F. A. A. | |
dc.contributor.author | Souza, Joao C. P. de | |
dc.contributor.author | Job, Aldo E. [UNESP] | |
dc.contributor.author | Crespilho, Frank N. | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2015-10-21T20:50:22Z | |
dc.date.available | 2015-10-21T20:50:22Z | |
dc.date.issued | 2015-01-01 | |
dc.description.abstract | Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (phi = 10 nm) decorated with AuNPs (phi = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications. | en |
dc.description.affiliation | UNESP, FCT, Dept Fis Quim &Biol, Presidente Prudente, SP, Brazil | |
dc.description.affiliation | Univ Sao Paulo, Inst Quim, Sao Carlos, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, FCT, Dept Fis Quim &Biol, Presidente Prudente, SP, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Brazilian agency INEO | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | FAPESP: 2013/14262-7 | |
dc.description.sponsorshipId | FAPESP: 2013/04663-4 | |
dc.description.sponsorshipId | CNPq: 306106/2013-2 | |
dc.description.sponsorshipId | CNPq: 478525/2013-3 | |
dc.description.sponsorshipId | FAPESP: 2011/23362-0 | |
dc.format.extent | 1835-1841 | |
dc.identifier | http://pubs.rsc.org/en/Content/ArticleLanding/2015/LC/C4LC01483A#!divAbstract | |
dc.identifier.citation | Lab On A Chip, v. 15, n. 8, p. 1835-1841, 2015. | |
dc.identifier.doi | 10.1039/c4lc01483a | |
dc.identifier.issn | 1473-0197 | |
dc.identifier.uri | http://hdl.handle.net/11449/129322 | |
dc.identifier.wos | WOS:000352088400005 | |
dc.language.iso | eng | |
dc.publisher | Royal Soc Chemistry | |
dc.relation.ispartof | Lab On A Chip | |
dc.relation.ispartofjcr | 5.995 | |
dc.relation.ispartofsjr | 2,158 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles | en |
dc.type | Artigo | |
dcterms.rightsHolder | Royal Soc Chemistry | |
dspace.entity.type | Publication | |
unesp.author.lattes | 6475585105456744[4] | |
unesp.author.orcid | 0000-0002-1979-8257[4] | |
unesp.author.orcid | 0000-0001-9962-3889[3] | |
unesp.author.orcid | 0000-0003-4830-652X[5] | |
unesp.author.orcid | 0000-0001-7924-7089[1] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências e Tecnologia, Presidente Prudente | pt |
unesp.department | Física, Química e Biologia - FCT | pt |