K+ATP channels-independent analgesic action of Crotalus durissus cumanensis venom
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The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 μg/kg) produced an antinociceptive effect during phase 2 in the formalin test. The effect of CDCM (200 μg/kg) was unaffected by the ATP-sensitive K+ channel blocker glibenclamide (2 mg/kg). These results suggest that CDCM is effective against acute pain. However, the ATP-sensitive K+ channels pathway is not contributable to the antinociceptive mechanism of CDCM.
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Crotalus durissus cumanensis venom, Glibenclamide, Nociception
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Inglês
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Natural Product Communications, v. 5, n. 7, p. 1103-1106, 2010.
