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Pancreas damage and intratracheal NiCl2 administration. Effects of nickel chloride.

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dc.contributor.authorNovelli, E. L.
dc.contributor.authorSforcin, J. M.
dc.contributor.authorRodrigues, N. L.
dc.contributor.authorRibas, B. O.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T09:06:46Z
dc.date.available2014-05-27T09:06:46Z
dc.date.issued1990-07-01
dc.description.abstractChanges in activities of Cu-Zn superoxide dismutase (SOD- E.C.1.15.1.1.) and lactate dehydrogenase (LDH- E.C.1.1.1.27.) and levels of copper, total protein, triglycerides, phospholipids and total lipids were investigated in pancreas of rats after intratracheal administration of NiCl2 (8.4 mumol/kg). Nickel chloride induced increased SOD activity in pancreas and erythrocytes. This elevation was related to increased copper and decreased phospholipid content in pancreas of these animals. In conclusion, the ability of an animal to tolerate nickel chloride induced damage was governed by a delicate balance between the generation of cytotoxic agents and the various pancreas defense capabilities.en
dc.format.extent54-58
dc.identifier.citationBoletin de estudios medicos y biologicos, v. 38, n. 3-4, p. 54-58, 1990.
dc.identifier.issn0067-9666
dc.identifier.scopus2-s2.0-0025459812
dc.identifier.urihttp://hdl.handle.net/11449/63999
dc.language.isoeng
dc.relation.ispartofBoletin de estudios medicos y biologicos
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectcopper
dc.subjectfree radical
dc.subjectlactate dehydrogenase
dc.subjectlipid
dc.subjectnickel
dc.subjectnickel chloride
dc.subjectprotein
dc.subjectsuperoxide
dc.subjectsuperoxide dismutase
dc.subjectanimal
dc.subjectchemistry
dc.subjectdrug effect
dc.subjectenzymology
dc.subjectinjection
dc.subjectmale
dc.subjectmetabolism
dc.subjectpancreas
dc.subjectrat
dc.subjectrat strain
dc.subjecttrachea
dc.subjectAnimal
dc.subjectCopper
dc.subjectFree Radicals
dc.subjectInjections
dc.subjectLactate Dehydrogenase
dc.subjectLipids
dc.subjectMale
dc.subjectNickel
dc.subjectPancreas
dc.subjectProteins
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSuperoxide Dismutase
dc.subjectSuperoxides
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTrachea
dc.titlePancreas damage and intratracheal NiCl2 administration. Effects of nickel chloride.en
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentMicrobiologia e Imunologia - IBBpt

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Botucatu - IBB - Instituto de Biociências