Expresión de la ciclooxigenasa-2 en los carcinomas mamarios caninos primarios metastásicos y no metastásicos
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The aim of this study was to detect the expression of ciclooxigenase-2 (COX-2) in metastatic primary carcinoma and non metastatic carcinoma, taking into consideration the relation between COX-2 and the progression of cancer. Evaluation of the COX-2 expression was achieved by immunohistochemistry analysis, using the primary polyclonal antibody anti-PGHS-2, clone PG 27, (Oxford Biomedical Research). The number of marked cells by the COX-2 antibody was higher (P > 0.001) in the metastatic primary carcinoma (81.25%) than non-metastatic (60.3%). There was a positive correlation between the number of labeled cells.
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Cancer, Ciclooxigenase-2, Dogs, Mammary neoplasm
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Espanhol
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Archivos de Medicina Veterinaria, v. 45, n. 3, p. 311-316, 2013.
