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Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans

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dc.contributor.authorMenezes, Raquel T. [UNESP]
dc.contributor.authorPereira, Thaís C. [UNESP]
dc.contributor.authorJunqueira, Juliana C. [UNESP]
dc.contributor.authorOliveira, Luciane D. [UNESP]
dc.contributor.authorScorzoni, Liliawna [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de Guarulhos (UNG)
dc.date.accessioned2023-03-01T20:41:57Z
dc.date.available2023-03-01T20:41:57Z
dc.date.issued2022-01-01
dc.description.abstractThis study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Instituto de Ciência e Tecnologia Departamento de Biociências e Diagnóstico Oral, Av Engenheiro Francisco José Longo 777 SP
dc.description.affiliationUniversidade de Guarulhos (UNG), Rua Engenheiro Prestes Maia 88 SP
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Instituto de Ciência e Tecnologia Departamento de Biociências e Diagnóstico Oral, Av Engenheiro Francisco José Longo 777 SP
dc.identifierhttp://dx.doi.org/10.1590/0001-3765202220211021
dc.identifier.citationAnais da Academia Brasileira de Ciencias, v. 94, n. 2, 2022.
dc.identifier.doi10.1590/0001-3765202220211021
dc.identifier.issn1678-2690
dc.identifier.issn0001-3765
dc.identifier.scopus2-s2.0-85129974671
dc.identifier.urihttp://hdl.handle.net/11449/240984
dc.language.isoeng
dc.relation.ispartofAnais da Academia Brasileira de Ciencias
dc.sourceScopus
dc.subjectCapsule
dc.subjectCryptococcus neoformans
dc.subjectDuloxetine hydrochloride
dc.subjectFluconazole
dc.subjectSynergistic combination
dc.titleSynergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformansen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0003-4250-5528[1]
unesp.author.orcid0000-0002-7206-3348[2]
unesp.author.orcid0000-0001-6646-6856[3]
unesp.author.orcid0000-0002-5465-9551[4]
unesp.author.orcid0000-0002-0178-6653[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, São José dos Campospt
unesp.departmentBiociências e Diagnóstico Bucal - ICTpt

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São José dos Campos - ICT - Instituto de Ciência e Tecnologia