Publicação: Heat stress induced alteration in bovine oocytes: functional and cellular aspects
dc.contributor.author | Lopes, Fabíola Freitas de Paula [UNESP] | |
dc.contributor.author | Lima, R. S. | |
dc.contributor.author | Risolia, Pedro Henrique B | |
dc.contributor.author | Ispada, J. | |
dc.contributor.author | Assumpção, Mayra Eelena Ortiz D'ávila de | |
dc.contributor.author | Visintin, José Antonio | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2016-04-01T18:46:52Z | |
dc.date.available | 2016-04-01T18:46:52Z | |
dc.date.issued | 2012 | |
dc.description.abstract | High environmental temperatures observed during the hot months of the year reduce fertility in lactating dairy cows. Summer heat stress depression in fertility is a multifactorial problem that affects physiological and cellular functions in several tissues. It has been shown that in addition to compromise follicular development, hormonal secretion, endometrial and embryonic function, heat stress also markedly reduces oocyte developmental ability. Oocyte susceptibility to elevated temperature can be detected during the germinal vesicle (GV) and oocyte maturation periods. In vivo (heat stress) and in vitro (heat shock) experiments indicated that exposure of bovine oocytes to elevated temperature affects the events required for successful oocyte maturation, fertilization and embryonic preimplantation development. This heat- induced decrease in oocyte function occurs due to a series of cellular alterations that affects nuclear and cytoplasmic compartments of the bovine oocyte. However, thermoprotective molecules such as growth factors and apoptosis inhibitors, which rescue heat- induced oocyte damage and developmental competence, can reverse these cellular changes. Therefore, identification of thermoprotective molecules can be considered as an alternative to modulate the effects of elevated temperature in reproductive function. | en |
dc.description.affiliation | Institute of Environmental Sciences, Chemistry and Pharmacy, Federal University of Sao Paulo, Diadema, SP, Brazil | |
dc.description.affiliation | Institute of Biosciences, Sao Paulo State University, Botucatu, SP, Brazil | |
dc.description.affiliation | Department of Animal Reproduction, University of São Paulo, São Paulo, SP, Brazil | |
dc.description.affiliationUnesp | Institute of Biosciences, Sao Paulo State University, Botucatu, SP, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorshipId | FAPESP: 2007/53323-0 | |
dc.description.sponsorshipId | CNPq: 478558/2008-2 | |
dc.format.extent | 395-403 | |
dc.identifier | http://www.cbra.org.br/portal/publicacoes/ar/2012/arjs2012.html | |
dc.identifier.citation | Animal Reproduction, v. 9, n. 3, p. 395-403, 2012. | |
dc.identifier.file | ISSN1806-9614-2012-09-03-395-403.pdf | |
dc.identifier.issn | 1806-9614 | |
dc.identifier.lattes | 8778339076231897 | |
dc.identifier.uri | http://hdl.handle.net/11449/137691 | |
dc.language.iso | eng | |
dc.relation.ispartof | Animal Reproduction | |
dc.relation.ispartofjcr | 0.991 | |
dc.relation.ispartofsjr | 0,308 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Currículo Lattes | |
dc.subject | Bovine | en |
dc.subject | Fertility | en |
dc.subject | Heat stress/shock | en |
dc.subject | Oocyte | en |
dc.title | Heat stress induced alteration in bovine oocytes: functional and cellular aspects | en |
dc.type | Artigo | pt |
dspace.entity.type | Publication | |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatu | pt |
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