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Heat stress induced alteration in bovine oocytes: functional and cellular aspects

dc.contributor.authorLopes, Fabíola Freitas de Paula [UNESP]
dc.contributor.authorLima, R. S.
dc.contributor.authorRisolia, Pedro Henrique B
dc.contributor.authorIspada, J.
dc.contributor.authorAssumpção, Mayra Eelena Ortiz D'ávila de
dc.contributor.authorVisintin, José Antonio
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-04-01T18:46:52Z
dc.date.available2016-04-01T18:46:52Z
dc.date.issued2012
dc.description.abstractHigh environmental temperatures observed during the hot months of the year reduce fertility in lactating dairy cows. Summer heat stress depression in fertility is a multifactorial problem that affects physiological and cellular functions in several tissues. It has been shown that in addition to compromise follicular development, hormonal secretion, endometrial and embryonic function, heat stress also markedly reduces oocyte developmental ability. Oocyte susceptibility to elevated temperature can be detected during the germinal vesicle (GV) and oocyte maturation periods. In vivo (heat stress) and in vitro (heat shock) experiments indicated that exposure of bovine oocytes to elevated temperature affects the events required for successful oocyte maturation, fertilization and embryonic preimplantation development. This heat- induced decrease in oocyte function occurs due to a series of cellular alterations that affects nuclear and cytoplasmic compartments of the bovine oocyte. However, thermoprotective molecules such as growth factors and apoptosis inhibitors, which rescue heat- induced oocyte damage and developmental competence, can reverse these cellular changes. Therefore, identification of thermoprotective molecules can be considered as an alternative to modulate the effects of elevated temperature in reproductive function.en
dc.description.affiliationInstitute of Environmental Sciences, Chemistry and Pharmacy, Federal University of Sao Paulo, Diadema, SP, Brazil
dc.description.affiliationInstitute of Biosciences, Sao Paulo State University, Botucatu, SP, Brazil
dc.description.affiliationDepartment of Animal Reproduction, University of São Paulo, São Paulo, SP, Brazil
dc.description.affiliationUnespInstitute of Biosciences, Sao Paulo State University, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2007/53323-0
dc.description.sponsorshipIdCNPq: 478558/2008-2
dc.format.extent395-403
dc.identifierhttp://www.cbra.org.br/portal/publicacoes/ar/2012/arjs2012.html
dc.identifier.citationAnimal Reproduction, v. 9, n. 3, p. 395-403, 2012.
dc.identifier.fileISSN1806-9614-2012-09-03-395-403.pdf
dc.identifier.issn1806-9614
dc.identifier.lattes8778339076231897
dc.identifier.urihttp://hdl.handle.net/11449/137691
dc.language.isoeng
dc.relation.ispartofAnimal Reproduction
dc.relation.ispartofjcr0.991
dc.relation.ispartofsjr0,308
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectBovineen
dc.subjectFertilityen
dc.subjectHeat stress/shocken
dc.subjectOocyteen
dc.titleHeat stress induced alteration in bovine oocytes: functional and cellular aspectsen
dc.typeArtigopt
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt

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