Publicação: Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol
dc.contributor.author | Saad, William A. [UNESP] | |
dc.contributor.author | Luiz, A. C. [UNESP] | |
dc.contributor.author | Camargo, L. A A [UNESP] | |
dc.contributor.author | Silveira, J. E N [UNESP] | |
dc.contributor.author | Fóglia, S. [UNESP] | |
dc.contributor.author | Menani, José Vanderlei [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-27T11:18:13Z | |
dc.date.available | 2014-05-27T11:18:13Z | |
dc.date.issued | 1997-04-01 | |
dc.description.abstract | We investigated the effects of losartan, an AT 1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l μl) into the LV blocked the pressor response induced by ANG II (12 ng/l μl) and carbachol (2 nmol/l μl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/l μl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure. | en |
dc.description.affiliation | Depto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SP | |
dc.description.affiliation | Depto. de Cie. Fisiológicas Faculdade de Odontologia UNESP, Rua Humaitá, 1680, 14801-903 Araraquara, SP | |
dc.description.affiliationUnesp | Depto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SP | |
dc.description.affiliationUnesp | Depto. de Cie. Fisiológicas Faculdade de Odontologia UNESP, Rua Humaitá, 1680, 14801-903 Araraquara, SP | |
dc.format.extent | 493-496 | |
dc.identifier | http://dx.doi.org/10.1590/S0100-879X1997000400010 | |
dc.identifier.citation | Brazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 493-496, 1997. | |
dc.identifier.doi | 10.1590/S0100-879X1997000400010 | |
dc.identifier.file | 2-s2.0-0030958097.pdf | |
dc.identifier.issn | 0100-879X | |
dc.identifier.lattes | 1023597870118105 | |
dc.identifier.scielo | S0100-879X1997000400010 | |
dc.identifier.scopus | 2-s2.0-0030958097 | |
dc.identifier.uri | http://hdl.handle.net/11449/65079 | |
dc.identifier.wos | WOS:A1997WT02000010 | |
dc.language.iso | eng | |
dc.relation.ispartof | Brazilian Journal of Medical and Biological Research | |
dc.relation.ispartofjcr | 1.492 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | carbachol | |
dc.subject | central angiotensin | |
dc.subject | pressor response | |
dc.subject | angiotensin | |
dc.subject | losartan | |
dc.subject | losartan potassium | |
dc.subject | ramipril | |
dc.subject | animal experiment | |
dc.subject | cholinergic system | |
dc.subject | conference paper | |
dc.subject | controlled study | |
dc.subject | intracerebroventricular drug administration | |
dc.subject | male | |
dc.subject | nonhuman | |
dc.subject | rat | |
dc.subject | renin angiotensin aldosterone system | |
dc.subject | Angiotensin-Converting Enzyme Inhibitors | |
dc.subject | Animals | |
dc.subject | Blood Pressure | |
dc.subject | Carbachol | |
dc.subject | Cerebral Ventricles | |
dc.subject | Cholinergic Agonists | |
dc.subject | Losartan | |
dc.subject | Male | |
dc.subject | Pressoreceptors | |
dc.subject | Ramipril | |
dc.subject | Rats | |
dc.subject | Rats, Sprague-Dawley | |
dc.subject | Receptors, Angiotensin | |
dc.subject | Renin-Angiotensin System | |
dc.subject | Animalia | |
dc.title | Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol | en |
dc.type | Trabalho apresentado em evento | |
dcterms.license | http://www.scielo.br/revistas/bjmbr/iaboutj.htm#Copyright | |
dspace.entity.type | Publication | |
unesp.author.lattes | 1023597870118105 | |
unesp.author.orcid | 0000-0003-1167-4441[6] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquara | pt |
unesp.department | Fisiologia e Patologia - FOAR | pt |
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