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Miniplates coated by plasma electrolytic oxidation improve bone healing of simulated femoral fractures on low bone mineral density rats

dc.contributor.authorMomesso, Gustavo Antonio Correa [UNESP]
dc.contributor.authorPolo, Tarik Ocon Braga [UNESP]
dc.contributor.authorda Silva, William Phillip Pereira [UNESP]
dc.contributor.authorBarbosa, Stéfany [UNESP]
dc.contributor.authorFreitas, Gileade P.
dc.contributor.authorLopes, Helena Bacha
dc.contributor.authorRosa, Adalberto Luiz
dc.contributor.authorCordeiro, Jairo Matozinho
dc.contributor.authorToro, Luan Felipe [UNESP]
dc.contributor.authorChiba, Fernando Yamamoto [UNESP]
dc.contributor.authorMatsushita, Doris Hissako [UNESP]
dc.contributor.authorLouzada, Mario Jefferson Quirino [UNESP]
dc.contributor.authorda Cruz, Nilson Cristino [UNESP]
dc.contributor.authorBarão, Valentim A.R.
dc.contributor.authorFaverani, Leonardo P. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2021-06-25T10:46:53Z
dc.date.available2021-06-25T10:46:53Z
dc.date.issued2021-01-01
dc.description.abstractThe treatment of polytrauma patients represents a great challenge in the maxillofacial and orthopedic surgery fields. Therefore, this study tested the hypothesis that the use of a bioactive coating (by plasma electrolytic oxidation, PEO) on titanium microplates could improve the fracture healing of low bone mineral density (BMD) rats. Thirty female rats underwent bilateral ovariectomy surgery (OVX), and 35 rats underwent fake surgery (SHAM). Three months later, animals were subjected to femoral fracture simulation and were fixed with either non-coated (CONV) or coated (PEO) titanium miniplates. Eight weeks postoperatively, microplate/bone complexes were analyzed through computed microtomography, histometric, confocal microscopy, molecular, and biomechanical analysis. Bioactive elements (Ca and P) were incorporated on the PEO microplate and the surface was modified in a volcano-like structure. In the microCT analysis the OVX/PEO group had greater values for Tb.Th (bone trabecular thickness), Tb.Sp (separation of bone trabeculae) and Tb.N (number of trabeculae) parameters compared to the OVX/CONV group. According to histometric analysis, the OVX/PEO group showed significantly higher new bone formation than the OVX/CONV group (P < 0.05). For the fluorochrome area, the OVX groups (PEO and CONV) showed greater values for calcein precipitation (old bone) than alizarin red (new bone). Molecular results showed greater values for proteins related to the final phase of bone formation (P < 0.05) in the OVX/PEO group. The OVX/PEO group showed higher bone/miniplate system resilience compared to the others (P < 0.05). It was concluded that PEO coating optimizes bone healing on simulated femoral fractures in low bone mineral density rats. This sheds new light in the treatment of osteoporotic patients with bone fractures.en
dc.description.affiliationDivision of Oral and Maxillofacial Surgery Department of Diagnosis and Surgery Aracatuba School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationBone Res Lab School of Dentistry of Ribeirao Preto University of São Paulo (USP)
dc.description.affiliationDepartment of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP)
dc.description.affiliationInstituto de Biociências de Botucatu (IBB) São Paulo State University (UNESP)
dc.description.affiliationDepartment of Basic Science Aracatuba School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas SBFis São Paulo State University (UNESP)
dc.description.affiliationLaboratory of Technological Plasmas (LaPTec) Science and Technology Institute of Sorocaba (ICTS) São Paulo State University (UNESP)
dc.description.affiliationUnespDivision of Oral and Maxillofacial Surgery Department of Diagnosis and Surgery Aracatuba School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespInstituto de Biociências de Botucatu (IBB) São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Basic Science Aracatuba School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas SBFis São Paulo State University (UNESP)
dc.description.affiliationUnespLaboratory of Technological Plasmas (LaPTec) Science and Technology Institute of Sorocaba (ICTS) São Paulo State University (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdUniversidade Estadual Paulista: 01.12.0530.00-FINEP/PROINFRA 01/2011
dc.description.sponsorshipIdFAPESP: 2016/20297-6
dc.description.sponsorshipIdFAPESP: 2018/00522-0
dc.identifierhttp://dx.doi.org/10.1016/j.msec.2020.111775
dc.identifier.citationMaterials Science and Engineering C, v. 120.
dc.identifier.doi10.1016/j.msec.2020.111775
dc.identifier.issn1873-0191
dc.identifier.issn0928-4931
dc.identifier.scopus2-s2.0-85097535106
dc.identifier.urihttp://hdl.handle.net/11449/206966
dc.language.isoeng
dc.relation.ispartofMaterials Science and Engineering C
dc.sourceScopus
dc.subjectBiochemical markers of bone turnover
dc.subjectBone histomorphometry
dc.subjectOsteoporosis
dc.subjectPreclinical studies
dc.titleMiniplates coated by plasma electrolytic oxidation improve bone healing of simulated femoral fractures on low bone mineral density ratsen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication8b3335a4-1163-438a-a0e2-921a46e0380d
relation.isOrgUnitOfPublication.latestForDiscovery8b3335a4-1163-438a-a0e2-921a46e0380d
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
unesp.departmentCirurgia e Clínica Integrada - FOApt
unesp.departmentCiências Básicas - FOApt

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