Miniplates coated by plasma electrolytic oxidation improve bone healing of simulated femoral fractures on low bone mineral density rats
dc.contributor.author | Momesso, Gustavo Antonio Correa [UNESP] | |
dc.contributor.author | Polo, Tarik Ocon Braga [UNESP] | |
dc.contributor.author | da Silva, William Phillip Pereira [UNESP] | |
dc.contributor.author | Barbosa, Stéfany [UNESP] | |
dc.contributor.author | Freitas, Gileade P. | |
dc.contributor.author | Lopes, Helena Bacha | |
dc.contributor.author | Rosa, Adalberto Luiz | |
dc.contributor.author | Cordeiro, Jairo Matozinho | |
dc.contributor.author | Toro, Luan Felipe [UNESP] | |
dc.contributor.author | Chiba, Fernando Yamamoto [UNESP] | |
dc.contributor.author | Matsushita, Doris Hissako [UNESP] | |
dc.contributor.author | Louzada, Mario Jefferson Quirino [UNESP] | |
dc.contributor.author | da Cruz, Nilson Cristino [UNESP] | |
dc.contributor.author | Barão, Valentim A.R. | |
dc.contributor.author | Faverani, Leonardo P. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | |
dc.date.accessioned | 2021-06-25T10:46:53Z | |
dc.date.available | 2021-06-25T10:46:53Z | |
dc.date.issued | 2021-01-01 | |
dc.description.abstract | The treatment of polytrauma patients represents a great challenge in the maxillofacial and orthopedic surgery fields. Therefore, this study tested the hypothesis that the use of a bioactive coating (by plasma electrolytic oxidation, PEO) on titanium microplates could improve the fracture healing of low bone mineral density (BMD) rats. Thirty female rats underwent bilateral ovariectomy surgery (OVX), and 35 rats underwent fake surgery (SHAM). Three months later, animals were subjected to femoral fracture simulation and were fixed with either non-coated (CONV) or coated (PEO) titanium miniplates. Eight weeks postoperatively, microplate/bone complexes were analyzed through computed microtomography, histometric, confocal microscopy, molecular, and biomechanical analysis. Bioactive elements (Ca and P) were incorporated on the PEO microplate and the surface was modified in a volcano-like structure. In the microCT analysis the OVX/PEO group had greater values for Tb.Th (bone trabecular thickness), Tb.Sp (separation of bone trabeculae) and Tb.N (number of trabeculae) parameters compared to the OVX/CONV group. According to histometric analysis, the OVX/PEO group showed significantly higher new bone formation than the OVX/CONV group (P < 0.05). For the fluorochrome area, the OVX groups (PEO and CONV) showed greater values for calcein precipitation (old bone) than alizarin red (new bone). Molecular results showed greater values for proteins related to the final phase of bone formation (P < 0.05) in the OVX/PEO group. The OVX/PEO group showed higher bone/miniplate system resilience compared to the others (P < 0.05). It was concluded that PEO coating optimizes bone healing on simulated femoral fractures in low bone mineral density rats. This sheds new light in the treatment of osteoporotic patients with bone fractures. | en |
dc.description.affiliation | Division of Oral and Maxillofacial Surgery Department of Diagnosis and Surgery Aracatuba School of Dentistry São Paulo State University (UNESP) | |
dc.description.affiliation | Bone Res Lab School of Dentistry of Ribeirao Preto University of São Paulo (USP) | |
dc.description.affiliation | Department of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP) | |
dc.description.affiliation | Instituto de Biociências de Botucatu (IBB) São Paulo State University (UNESP) | |
dc.description.affiliation | Department of Basic Science Aracatuba School of Dentistry São Paulo State University (UNESP) | |
dc.description.affiliation | Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas SBFis São Paulo State University (UNESP) | |
dc.description.affiliation | Laboratory of Technological Plasmas (LaPTec) Science and Technology Institute of Sorocaba (ICTS) São Paulo State University (UNESP) | |
dc.description.affiliationUnesp | Division of Oral and Maxillofacial Surgery Department of Diagnosis and Surgery Aracatuba School of Dentistry São Paulo State University (UNESP) | |
dc.description.affiliationUnesp | Instituto de Biociências de Botucatu (IBB) São Paulo State University (UNESP) | |
dc.description.affiliationUnesp | Department of Basic Science Aracatuba School of Dentistry São Paulo State University (UNESP) | |
dc.description.affiliationUnesp | Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas SBFis São Paulo State University (UNESP) | |
dc.description.affiliationUnesp | Laboratory of Technological Plasmas (LaPTec) Science and Technology Institute of Sorocaba (ICTS) São Paulo State University (UNESP) | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Universidade Estadual Paulista | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | Universidade Estadual Paulista: 01.12.0530.00-FINEP/PROINFRA 01/2011 | |
dc.description.sponsorshipId | FAPESP: 2016/20297-6 | |
dc.description.sponsorshipId | FAPESP: 2018/00522-0 | |
dc.identifier | http://dx.doi.org/10.1016/j.msec.2020.111775 | |
dc.identifier.citation | Materials Science and Engineering C, v. 120. | |
dc.identifier.doi | 10.1016/j.msec.2020.111775 | |
dc.identifier.issn | 1873-0191 | |
dc.identifier.issn | 0928-4931 | |
dc.identifier.scopus | 2-s2.0-85097535106 | |
dc.identifier.uri | http://hdl.handle.net/11449/206966 | |
dc.language.iso | eng | |
dc.relation.ispartof | Materials Science and Engineering C | |
dc.source | Scopus | |
dc.subject | Biochemical markers of bone turnover | |
dc.subject | Bone histomorphometry | |
dc.subject | Osteoporosis | |
dc.subject | Preclinical studies | |
dc.title | Miniplates coated by plasma electrolytic oxidation improve bone healing of simulated femoral fractures on low bone mineral density rats | en |
dc.type | Artigo | pt |
dspace.entity.type | Publication | |
relation.isOrgUnitOfPublication | 8b3335a4-1163-438a-a0e2-921a46e0380d | |
relation.isOrgUnitOfPublication.latestForDiscovery | 8b3335a4-1163-438a-a0e2-921a46e0380d | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatuba | pt |
unesp.department | Cirurgia e Clínica Integrada - FOA | pt |
unesp.department | Ciências Básicas - FOA | pt |