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Dynamic sex chromosome expression in Drosophila male germ cells

dc.contributor.authorMahadevaraju, Sharvani
dc.contributor.authorFear, Justin M.
dc.contributor.authorAkeju, Miriam
dc.contributor.authorGalletta, Brian J.
dc.contributor.authorPinheiro, Mara M. L. S.
dc.contributor.authorAvelino, Camila C.
dc.contributor.authorCabral-de-Mello, Diogo C. [UNESP]
dc.contributor.authorConlon, Katie
dc.contributor.authorDell’Orso, Stafania
dc.contributor.authorDemere, Zelalem
dc.contributor.authorMansuria, Kush
dc.contributor.authorMendonça, Carolina A.
dc.contributor.authorPalacios-Gimenez, Octavio M.
dc.contributor.authorRoss, Eli
dc.contributor.authorSavery, Max
dc.contributor.authorYu, Kevin
dc.contributor.authorSmith, Harold E.
dc.contributor.authorSartorelli, Vittorio
dc.contributor.authorYang, Haiwang
dc.contributor.authorRusan, Nasser M.
dc.contributor.authorVibranovski, Maria D.
dc.contributor.authorMatunis, Erika
dc.contributor.authorOliver, Brian
dc.contributor.institutionNational Institutes of Health
dc.contributor.institutionJohns Hopkins University School of Medicine
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUppsala University
dc.contributor.institutionNorthwestern University
dc.date.accessioned2021-06-25T10:52:09Z
dc.date.available2021-06-25T10:52:09Z
dc.date.issued2021-12-01
dc.description.abstractGiven their copy number differences and unique modes of inheritance, the evolved gene content and expression of sex chromosomes is unusual. In many organisms the X and Y chromosomes are inactivated in spermatocytes, possibly as a defense mechanism against insertions into unpaired chromatin. In addition to current sex chromosomes, Drosophila has a small gene-poor X-chromosome relic (4th) that re-acquired autosomal status. Here we use single cell RNA-Seq on fly larvae to demonstrate that the single X and pair of 4th chromosomes are specifically inactivated in primary spermatocytes, based on measuring all genes or a set of broadly expressed genes in testis we identified. In contrast, genes on the single Y chromosome become maximally active in primary spermatocytes. Reduced X transcript levels are due to failed activation of RNA-Polymerase-II by phosphorylation of Serine 2 and 5.en
dc.description.affiliationLaboratory of Cellular and Developmental Biology National Institute of Diabetes and Kidney and Digestive Diseases National Institutes of Health
dc.description.affiliationDepartment of Cell Biology Johns Hopkins University School of Medicine, 725 N. Wolfe Street
dc.description.affiliationCell Biology and Physiology Center National Heart Lung and Blood Institute National Institutes of Health
dc.description.affiliationDepartment of Genetics and Evolutionary Biology Institute of Biosciences University of São Paulo
dc.description.affiliationInstituto de Biociências/IB Departamento de Biologia Geral e Aplicada UNESP—Universidade Estadual Paulista Rio Claro
dc.description.affiliationLaboratory of Muscle Stem Cells and Gene Regulation National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health
dc.description.affiliationGenomics Core National Institute of Diabetes and Kidney and Digestive Diseases National Institutes of Health
dc.description.affiliationDepartment of Evolutionary Biology and Department of Organismal Biology Systematic Biology Evolutionary Biology Centre Uppsala University
dc.description.affiliationDepartment of Pharmacology Feinberg School of Medicine Northwestern University
dc.description.affiliationUnespInstituto de Biociências/IB Departamento de Biologia Geral e Aplicada UNESP—Universidade Estadual Paulista Rio Claro
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases
dc.description.sponsorshipIdNational Institute of Diabetes and Digestive and Kidney Diseases: DK015600
dc.identifierhttp://dx.doi.org/10.1038/s41467-021-20897-y
dc.identifier.citationNature Communications, v. 12, n. 1, 2021.
dc.identifier.doi10.1038/s41467-021-20897-y
dc.identifier.issn2041-1723
dc.identifier.scopus2-s2.0-85100732424
dc.identifier.urihttp://hdl.handle.net/11449/207265
dc.language.isoeng
dc.relation.ispartofNature Communications
dc.sourceScopus
dc.titleDynamic sex chromosome expression in Drosophila male germ cellsen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0002-2732-449X[2]
unesp.author.orcid0000-0002-6417-0637[5]
unesp.author.orcid0000-0002-1306-2820[9]
unesp.author.orcid0000-0002-3517-5973[17]
unesp.author.orcid0000-0002-9284-3675[18]
unesp.author.orcid0000-0002-3455-4891[23]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
unesp.departmentBiologia - IBpt

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