Logotipo do repositório
 

Publicação:
Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion study

dc.contributor.authorNeto, Pedro Fraccarolli
dc.contributor.authorda Silva, Agnaldo Fernando Baldo
dc.contributor.authorMoro, Evandro Bilha [UNESP]
dc.contributor.authorPilarski, Fabiana [UNESP]
dc.contributor.authorde Freitas, Osvaldo
dc.contributor.authorMooney, Mark H.
dc.contributor.authorPaschoal, Jonas Augusto Rizzato
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionQueen's University Belfast
dc.date.accessioned2019-10-06T16:15:00Z
dc.date.available2019-10-06T16:15:00Z
dc.date.issued2019-05-01
dc.description.abstractDue to the lack of regulated drugs for aquaculture, the present study considered specific issues relating to environmental and food safety aspects concerning the potential use of emamectin benzoate (EMA) in freshwater fishes such as tilapia (Oreochromis niloticus) – an important commercial fish species worldwide. The residual depletion of EMA (EMA-B 1a ) in fillet (muscle plus skin in natural proportions) of tilapia treated with a daily dose of 50 μg/kg BW during seven consecutive days was evaluated. To facilitate this, analytical methods for quantitation of EMA in fish feed and in fish fillet employing LC-MS/MS were developed and validated. To eliminate the risk of EMA leaching from feed into the aquatic environment during fish medication via oral administration, a promising procedure for drug incorporation into feed involving the coating of feed pellets with ethyl cellulose polymer containing EMA was evaluated. The medicated feed exhibited good homogeneity (CV < 2.1%) with negligible EMA release (< LOQ) when the medicated feed remained in the water for up to 20 min. Depletion study analysis revealed the highest EMA concentration obtained in fish fillet to be 13.3 ng/g. Therefore, under the employed rearing conditions of this study, the obtained results did not evidence requirement for a minimum withdrawal period to be proposed considering the maximum residue limit of 100 μg/g for fish muscle. In response to the well-recognized demands and need for new alternative veterinary drugs for use within aquaculture, this study offers impetus for consideration of EMA use in tilapia taking into account environmental contamination and food safety issues.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas de Ribeirão Preto Departamento de Física e Química Universidade de São Paulo (USP)
dc.description.affiliationCentro de Aquacultura da Unesp Universidade do Estado de São Paulo (Unesp)
dc.description.affiliationFaculdade de Ciências Farmacêuticas de Ribeirão Preto Departamento de Ciências Farmacêuticas Universidade de São Paulo (USP)
dc.description.affiliationInstitute for Global Food Security School of Biological Sciences Queen's University Belfast
dc.description.affiliationUnespCentro de Aquacultura da Unesp Universidade do Estado de São Paulo (Unesp)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/18334-0
dc.description.sponsorshipIdFAPESP: 2014/50755-0
dc.format.extent524-529
dc.identifierhttp://dx.doi.org/10.1016/j.foodres.2019.01.033
dc.identifier.citationFood Research International, v. 119, p. 524-529.
dc.identifier.doi10.1016/j.foodres.2019.01.033
dc.identifier.issn1873-7145
dc.identifier.issn0963-9969
dc.identifier.scopus2-s2.0-85060350844
dc.identifier.urihttp://hdl.handle.net/11449/188654
dc.language.isoeng
dc.relation.ispartofFood Research International
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAquaculture
dc.subjectEmamectin benzoate
dc.subjectFood safety
dc.subjectResidual depletion
dc.subjectTilapia
dc.subjectVeterinary drug residues
dc.subjectWithdrawal period
dc.titleEmamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion studyen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0002-7372-0936[7]

Arquivos