Publicação: Characterization and biological studies of a new platinum(II) complex with the amino acid L-alliin
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Taylor & Francis Ltd
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
Synthesis and characterization of a new Pt(II) complex with the amino acid L-alliin (S-allyl-L-cysteine sulfoxide, C(6)H(11)NO(3)S) are described. Elemental and mass spectrometric analyses of the solid complex are consistent with [PtCl(2)(alliin)], or [PtCl(2)(C(6)H(11)NO(3)S)]. (13)C nuclear magnetic resonance (NMR), [(1)H-(15)N] two dimensional (2D) NMR and infrared spectroscopy indicate coordination of the ligand to Pt(II) through the N and S atoms. The complex is very soluble in dimethyl sulfoxide. Biological analysis for evaluation of a potential cytotoxic effect of the complex was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented moderate cytotoxic activity, inducing about 40% cell death at a concentration of 400 mol L(-1).
Descrição
Palavras-chave
S-allyl-L-cysteine sulfoxide, L-alliin, platinum(II), (15)N resonance, cytotoxicity
Idioma
Inglês
Como citar
Journal of Coordination Chemistry. Abingdon: Taylor & Francis Ltd, v. 61, n. 15, p. 2470-2477, 2008.
