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Blends of cross-linked high amylose starch/pectin loaded with diclofenac

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dc.contributor.authorSoares, Grazielle Arantes [UNESP]
dc.contributor.authorCastro, Ana Doris de [UNESP]
dc.contributor.authorCury, Beatriz S.F. [UNESP]
dc.contributor.authorEvangelista, Raul Cesar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:27:33Z
dc.date.available2014-05-27T11:27:33Z
dc.date.issued2013-01-02
dc.description.abstractPolymers blends represent an important approach to obtain materials with modulated properties to reach different and desired properties in designing drug delivery systems in order to fulfill therapeutic needs. The aim of this work was to evaluate the influence of drug loading and polymer ratio on the physicochemical properties of microparticles of cross-linked high amylose starch-pectin blends loaded with diclofenac for further application in controlled drug delivery systems. Thermal analysis and X-ray diffractograms evidenced the occurrence of drug-polymer interactions and the former pointed also to an increase in thermal stability due to drug loading. The rheological properties demonstrated that drug loading resulted in formation of weaker gels while the increase of pectin ratio contributes to origin stronger structures. © 2012 Elsevier Ltd.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos Universidade Estadual Paulista UNESP, Rodovia Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos Universidade Estadual Paulista UNESP, Rodovia Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP
dc.format.extent135-142
dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2012.08.014
dc.identifier.citationCarbohydrate Polymers, v. 91, n. 1, p. 135-142, 2013.
dc.identifier.doi10.1016/j.carbpol.2012.08.014
dc.identifier.file2-s2.0-84865459434.pdf
dc.identifier.issn0144-8617
dc.identifier.lattes5361569184579557
dc.identifier.scopus2-s2.0-84865459434
dc.identifier.urihttp://hdl.handle.net/11449/74340
dc.identifier.wosWOS:000310253800017
dc.language.isoeng
dc.relation.ispartofCarbohydrate Polymers
dc.relation.ispartofjcr5.158
dc.relation.ispartofsjr1,428
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectHigh amylose starch
dc.subjectPectin
dc.subjectPolymer blends
dc.subjectRheology
dc.subjectThermal analysis
dc.subjectX-ray diffraction
dc.subjectControlled drug delivery systems
dc.subjectDiclofenac
dc.subjectDrug delivery system
dc.subjectDrug loading
dc.subjectDrug-polymer interaction
dc.subjectHigh amylose
dc.subjectMicro-particles
dc.subjectPhysicochemical property
dc.subjectRheological property
dc.subjectX-ray diffractograms
dc.subjectControlled drug delivery
dc.subjectCrosslinking
dc.subjectFunctional polymers
dc.subjectMaterials properties
dc.subjectStarch
dc.subjectThermoanalysis
dc.subjectX ray diffraction
dc.subjectLoading
dc.subjectamylose
dc.subjectdiclofenac
dc.subjectdrug carrier
dc.subjectmicrosphere
dc.subjectpectin
dc.subjectchemistry
dc.subjectflow kinetics
dc.subjectparticle size
dc.subjecttemperature
dc.subjectAmylose
dc.subjectDrug Carriers
dc.subjectMicrospheres
dc.subjectParticle Size
dc.subjectPectins
dc.subjectTemperature
dc.titleBlends of cross-linked high amylose starch/pectin loaded with diclofenacen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dspace.entity.typePublication
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscoverye214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes5361569184579557
unesp.author.orcid0000-0003-3020-9238[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas