Publicação: Magnetic images of pharmaceutical dosage forms in the human gastrointestinal tract
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Trabalho apresentado em evento
Direito de acesso
Acesso aberto
Resumo
Oral administration with solid dosage forms is a common route in the drug therapy widely used. The drug release by the disintegration process occurs in several gastrointestinal tract (GIT) regions. AC Biosusceptometry (ACB) was originally proposal to characterize the disintegration process of tablets in vitro and in the human stomach, through changes in magnetic signals. The aim of this work was to employ a multisensor ACB system to monitoring magnetic tablets and capsules in the human GIT and to obtain the magnetic images of the disintegration process. The ACB showed accuracy to quantify the gastric residence time, the intestinal transit time and the magnetic images allowed to visualize the disintegration of magnetic formulations in the GIT. The ACB is a non-invasive, radiation free technique, completely safe and harmless to the volunteers and had demonstrated potential to evaluate pharmaceutical dosage forms in the human gastrointestinal tract. © 2005 IEEE.
Descrição
Palavras-chave
AC Biosusceptometry, Disintegration, Gastrointestinal tract, Magnetic images, Biomedical engineering, Decomposition, Gastroenterology, Medical imaging, Sensor data fusion, AC Biosusceptometry (ACB), Gastrointestinal tract (GIT) regions, Magnetic tablets, Drug dosage
Idioma
Inglês
Como citar
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, v. 7 VOLS, p. 7254-7257.
