Publicação: Synthesis of the Peptide Ac-Wahx-KTTKS and Evaluation of the Ability to Induce In Vitro Collagen Synthesis
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Bentham Science Publ Ltd
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
In this work, we report the synthesis of a peptide analogue of the KTTKS, termed Ac-Wahx-KTTKS and evaluate its cytotoxicity and role in biosynthesis of collagen for future application in skin aging. The peptide was obtained with purity higher than 97.5%. In the cytotoxicity assay, we observed non-toxic effects for Ac-WAhx-KTTKS at concentrations below 600 mu M for HaCaT and 500 mu M for HepG2 cells, respectively. After 24 and 48 h it was possible to observe significant changes in collagen synthesis in the groups treated with various concentrations of the peptide. In conclusion, the Ac-Wahx-KTTKS peptide increased collagen synthesis in fibroblasts by 80% and it is a promising candidate for improving skin aging.
Descrição
Palavras-chave
Ac-WAhx-KTTKS, antiaging, collagen biosynthesis, cytotoxicity, peptide synthesis, skin functions
Idioma
Inglês
Como citar
Protein And Peptide Letters. Sharjah: Bentham Science Publ Ltd, v. 23, n. 6, p. 544-547, 2016.
