Publicação:
Experimental Basis and New Insights for Cell Therapy in Chronic Obstructive Pulmonary Disease

dc.contributor.authorde Faria, Carolina Arruda
dc.contributor.authorKozma, Rodrigo de las Heras
dc.contributor.authorStessuk, Talita
dc.contributor.authorRibeiro-Paes, Joao Tadeu [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:31:30Z
dc.date.available2014-05-20T15:31:30Z
dc.date.issued2012-12-01
dc.description.abstractChronic Obstructive Pulmonary Disease (COPD) can be briefly described as air flow limitation and chronic dyspnea associated to an inflammatory response of the respiratory tract to noxious particles and gases. Its main feature is the obstruction of airflow and consequent chronic dyspnea. Despite recent advances, and the development of new therapeutic, medical and clinical approaches, a curative therapy is yet to be achieved. Therapies involving the use of tissue-specific or donor derived cells present a promising alternative in the treatment of degenerative diseases and injuries. Recent studies demonstrate that mesenchymal stem cells have the capacity to modulate immune responses in acute lung injury and pulmonary fibrosis in animal models, as well as in human patients. Due to these aspects, different groups raised the possibility that the stem cells from different sources, such as those found in bone marrow or adipose tissue, could act preventing the emphysematous lesion progression. In this paper, it is proposed a review of the current state of the art and future perspectives on the use of cell therapy in obstructive lung diseases.en
dc.description.affiliationUniv São Paulo, Program Postgrad Genet, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Postgrad Program Biotechnol, Instituto Butantan, IPT, BR-09500900 São Paulo, Brazil
dc.description.affiliationUniv State São Paulo UNESP, Dept Biol Sci, São Paulo, Brazil
dc.description.affiliationUnespUniv State São Paulo UNESP, Dept Biol Sci, São Paulo, Brazil
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipMunicipal Government of Assis
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1236-1244
dc.identifierhttp://dx.doi.org/10.1007/s12015-012-9410-7
dc.identifier.citationStem Cell Reviews and Reports. Totowa: Humana Press Inc, v. 8, n. 4, p. 1236-1244, 2012.
dc.identifier.doi10.1007/s12015-012-9410-7
dc.identifier.issn1550-8943
dc.identifier.urihttp://hdl.handle.net/11449/40618
dc.identifier.wosWOS:000311510600020
dc.language.isoeng
dc.publisherHumana Press Inc
dc.relation.ispartofStem Cell Reviews and Reports
dc.relation.ispartofjcr3.612
dc.relation.ispartofsjr1,323
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectChronic obstructive pulmonary diseaseen
dc.subjectCell therapyen
dc.subjectStem cellsen
dc.subjectBone marrowen
dc.titleExperimental Basis and New Insights for Cell Therapy in Chronic Obstructive Pulmonary Diseaseen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderHumana Press Inc
dspace.entity.typePublication
unesp.author.orcid0000-0002-7645-5891[4]
unesp.author.orcid0000-0001-8086-1262[1]

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