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Publicação:
Antifungal activity of 2′-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp

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dc.contributor.authorMedina-Alarcón, Kaila P [UNESP]
dc.contributor.authorSingulani, Junya De L. [UNESP]
dc.contributor.authorDutra, Luiz A.
dc.contributor.authorPitangui, Nayla De S. [UNESP]
dc.contributor.authorPereira-Da-Silva, Marcelo A.
dc.contributor.authorDos Santos, Mariana B. [UNESP]
dc.contributor.authorAyusso, Gabriela M. [UNESP]
dc.contributor.authorRegasini, Luis O. [UNESP]
dc.contributor.authorSoares, Christiane P. [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorMendes-Giannini, Maria J.S. [UNESP]
dc.contributor.authorFusco-Almeida, Ana M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUNICEP
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2020-12-12T01:58:02Z
dc.date.available2020-12-12T01:58:02Z
dc.date.issued2020-01-01
dc.description.abstractAim: This study aimed to evaluate the activity of 2′-hydroxychalcone-loaded in nanoemulsion (NLS + 2′chalc), the cytotoxic effect and toxicity against Paracoccidioides brasiliensis and Paracoccidioides lutzii using a zebrafish model. Materials & methods: Preparation and physical-chemical characterization of nanoemulsion (NLS) and NLS + 2′chalc were performed. MIC and minimum fungicide concentration, cytotoxicity and toxicity were also evaluated in the Danio rerio model. Results: NLS + 2′chalc showed fungicidal activity against Paracoccidioides spp. without cytotoxicity in MRC5 and HepG2 lines. It also had high selectivity index values and no toxicity in the zebrafish model based on MIC values. Conclusion: NLS + 2′chalc is a potential new alternative treatment for paracoccidioidomycosis.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Proteomics Center Mycology Laboratory
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Department of Drugs and Medicines
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Department of Clinical Analysis Cytology Laboratory
dc.description.affiliationInstitute of Physics of Sao Carlos IFSC/USP
dc.description.affiliationPaulista Central University Center UNICEP
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Instituto de Biociências Letras e Ciências Exatas São José do Rio Preto Department of Chemistry and Environmental Sciences
dc.description.affiliationStructural Genomics Consortium Research Institute-UNICAMP
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Proteomics Center Mycology Laboratory
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Department of Drugs and Medicines
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Department of Clinical Analysis Cytology Laboratory
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Instituto de Biociências Letras e Ciências Exatas São José do Rio Preto Department of Chemistry and Environmental Sciences
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2016/05581-0
dc.format.extent21-33
dc.identifierhttp://dx.doi.org/10.2217/fmb-2019-0095
dc.identifier.citationFuture Microbiology, v. 15, n. 1, p. 21-33, 2020.
dc.identifier.doi10.2217/fmb-2019-0095
dc.identifier.issn1746-0921
dc.identifier.issn1746-0913
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.scopus2-s2.0-85080852738
dc.identifier.urihttp://hdl.handle.net/11449/200111
dc.language.isoeng
dc.relation.ispartofFuture Microbiology
dc.sourceScopus
dc.subjectantifungal
dc.subjectnanostructured lipid system
dc.subjectParacoccidioides spp.
dc.subjectzebrafish model
dc.titleAntifungal activity of 2′-hydroxychalcone loaded in nanoemulsion against Paracoccidioides sppen
dc.typeArtigopt
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
unesp.author.lattes1768025290373669[9]
unesp.author.orcid0000-0003-1740-7360[9]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentFármacos e Medicamentos - FCFpt
unesp.departmentQuímica e Ciências Ambientais - IBILCEpt

Arquivos

Coleções

Araraquara - FCF - Faculdade de Ciências Farmacêuticas
São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas