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Immunization protected well nourished mice but not undernourished ones from lung injury in Methicillin-resistant Staphylococcus aureus (MRSA) infection

dc.contributor.authorDonega Franca, Thais Graziela [UNESP]
dc.contributor.authorWatanabe Ishikawa, Larissa Lumi [UNESP]
dc.contributor.authorGoncalves Zorzella-Pezavento, Sofia Fernanda [UNESP]
dc.contributor.authorChiuso-Minicucci, Fernanda [UNESP]
dc.contributor.authorFujiara Guerino, Clara Pires [UNESP]
dc.contributor.authorRibeiro de Souza da Cunha, Maria de Lourdes [UNESP]
dc.contributor.authorSartori, Alexandrina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:51:10Z
dc.date.available2014-05-20T13:51:10Z
dc.date.issued2009-11-23
dc.description.abstractBackground: Staphylococcus aureus methicillin-resistant (MRSA) has been frequently isolated from endotracheal and lung puncture aspirates in malnourished children with pneumonia. In this work we evaluated the susceptibility of undernourished BALB/c mice and its ability to mount a protective immunity against MRSA with emphasis on the lung involvement.Results: BALB/c mice submitted to a 20% dietary restriction during 20 days presented a significant decrease in body weight, lymphocyte number and also atrophy in thymus and intestinal epithelium. Determination of bacterial load by the number of colony forming units (CFU) indicated a similar susceptibility whereas the findings of Gram stain clearly suggested a higher amount of bacteria in the lungs of normal mice than in the undernourished ones. Immunization reduced bacterial growth in the lungs of normal mice but not in the undernourished ones. Histopathological analysis showed that inflammation appeared in the lungs from normal mice only after infection and that immunization prevented this pulmonary inflammatory process. on the other hand, undernourished mice presented lung inflammation even before infection. In addition, the degree of this inflammatory process did not change with infection or previous immunization.Conclusion: Our results indicated that lung injury during MRSA infection is prevented by previous immunization in well nourished but not in undernourished mice.en
dc.description.affiliationUNESP, São Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, São Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent7
dc.identifierhttp://dx.doi.org/10.1186/1471-2180-9-240
dc.identifier.citationBmc Microbiology. London: Biomed Central Ltd., v. 9, p. 7, 2009.
dc.identifier.doi10.1186/1471-2180-9-240
dc.identifier.fileWOS000272410800003.pdf
dc.identifier.issn1471-2180
dc.identifier.lattes4977572416129527
dc.identifier.urihttp://hdl.handle.net/11449/18271
dc.identifier.wosWOS:000272410800003
dc.language.isoeng
dc.publisherBiomed Central Ltd.
dc.relation.ispartofBMC Microbiology
dc.relation.ispartofjcr2.829
dc.relation.ispartofsjr1,242
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleImmunization protected well nourished mice but not undernourished ones from lung injury in Methicillin-resistant Staphylococcus aureus (MRSA) infectionen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
dcterms.rightsHolderBiomed Central Ltd.
dspace.entity.typePublication
unesp.author.lattes4977572416129527[7]
unesp.author.orcid0000-0003-4557-3331[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentMicrobiologia e Imunologia - IBBpt

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