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Effects of morin on snake venom phospholipase A(2) (PLA(2))

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dc.contributor.authorIglesias, C. V.
dc.contributor.authorAparicio, R.
dc.contributor.authorRodrigues-Simioni, L.
dc.contributor.authorCamargo, E. A.
dc.contributor.authorAntunes, E.
dc.contributor.authorMarangoni, S.
dc.contributor.authorToyoma, D. D.
dc.contributor.authorBeriam, LOS
dc.contributor.authorMonteiro, HSA
dc.contributor.authorToyama, M. H.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Biol
dc.contributor.institutionInst Quim
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.contributor.institutionUFC
dc.contributor.institutionInst Biol Campinas
dc.date.accessioned2014-05-20T13:12:16Z
dc.date.available2014-05-20T13:12:16Z
dc.date.issued2005-12-01
dc.description.abstractFlavonoids are potent anti-inflammatory compounds isolated from several plant extracts, and have been used experimentally against inflammatory processes. In this work, a PLA(2) isolated from the Crotalus durissus cascavella venom and rat paw oedema were used as a model to. study the effect of flavonoids on PLA(2). We observed that a treatment of PLA(2) with morin induces several modifications in the aromatic amino acids, with accompanying changes in its amino acid composition. In addition, results from circular dichroism spectroscopy and UV scanning revealed important structural modifications. Concomitantly, a considerable decrease in the enzymatic and antibacterial activities was observed, even though anti-inflammatory and neurotoxic activities were not affected. These apparent controversial results may be an indication that PLA(2) possess a second pharmacological site which does not affect or depend on the enzymatic activity. (c) 2005 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Sao Vicente, CLP, UNESP, Sao Vicente, SP, Brazil
dc.description.affiliationInst Biol, Dept Bioquim, Campinas, SP, Brazil
dc.description.affiliationInst Quim, Campinas, SP, Brazil
dc.description.affiliationUNICAMP, Fac Med, Dept Farmacol, Campinas, SP, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Fac Ciências Biol Exatas & Expt, Campinas, SP, Brazil
dc.description.affiliationUFC, Dept Farmacol, Fortaleza, Ceara, Brazil
dc.description.affiliationInst Biol Campinas, Ctr Expt, Lab Bacteriol Vegetal, Campinas, SP, Brazil
dc.description.affiliationUnespUniv Sao Vicente, CLP, UNESP, Sao Vicente, SP, Brazil
dc.format.extent751-758
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2005.07.017
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 46, n. 7, p. 751-758, 2005.
dc.identifier.doi10.1016/j.toxicon.2005.07.017
dc.identifier.issn0041-0101
dc.identifier.lattes8573195327542061
dc.identifier.urihttp://hdl.handle.net/11449/252
dc.identifier.wosWOS:000233491400005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPLA(2)pt
dc.subjectcircular dichroism spectroscopypt
dc.subjectantibacterial activitypt
dc.subjectflavonoidspt
dc.subjectmorinpt
dc.subjectCrotalus durissus cascavellapt
dc.subjectneurotoxicpt
dc.titleEffects of morin on snake venom phospholipase A(2) (PLA(2))en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes8573195327542061
unesp.author.orcid0000-0001-6836-3084[10]
unesp.author.orcid0000-0003-2201-8247[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, São Vicentept
unesp.departmentCiências Biológicas - IBCLPpt

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