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Morphological and molecular analysis of apoptosis in the corpus cavernosum of rats submitted to a chronic alcoholism model1

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dc.contributor.authorMeirelles, Rogério José de Azevedo
dc.contributor.authorNeto, Fermino Sanches Lizarte
dc.contributor.authorCirino, Mucio Luiz de Assis
dc.contributor.authorNovais, Paulo Cezar
dc.contributor.authorGula, Isabella Stracieri
dc.contributor.authorSilva, Jairo Pinheiro da
dc.contributor.authorTazzima, Maria de Fátima Galli Sorita
dc.contributor.authorFazan, Valéria Paula Sassoli
dc.contributor.authorDurand, Marina Toledo
dc.contributor.authorTirapelli, Daniela Pretti da Cunha [UNESP]
dc.contributor.authorde Carvalho, Camila Albuquerque Melo
dc.contributor.authorSchimming, Bruno César [UNESP]
dc.contributor.authorMolina, Carlos Augusto Fernandes
dc.contributor.authorJunior, Silvio Tucci
dc.contributor.authorTirapelli, Luis Fernando
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade de Marília (UNIMAR)
dc.contributor.institutionUniversidade de Ribeirão Preto (UNAERP)
dc.contributor.institutionFaculdade de Taquaritinga (FTGA)
dc.contributor.institutionUNAERP
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T02:43:46Z
dc.date.available2020-12-12T02:43:46Z
dc.date.issued2020-01-01
dc.description.abstractPurpose: To evaluate the effect of chronic alcoholism on morphometry and apoptosis mechanism and correlate with miRNA-21 expression in the corpus cavernosum of rats. Methods: Twenty-four rats were divided into two experimental groups: Control (C) and Alcoholic group (A). After two weeks of an adaptive phase, rats from group A received only ethanol solution (20%) during 7 weeks. The morphometric and caspase-3 immunohistochemistry analysis were performed in the corpus cavernosum. The miRNA-21 expression was analyzed in blood and cavernous tissue. Results: Chronic ethanol consumption decreased cavernosal smooth muscle area of alcoholic rats. The protein expression of caspase 3 in the corpus cavernosum was higher in A compared to the C group. There was no difference in the expression of miRNA-21 in serum and cavernous tissue between the groups. Conclusion: Chronic ethanol consumption reduced smooth muscle area and increased caspase 3 in the corpus cavernosum of rats, without altered serum and cavernosal miR-21 gene expression.en
dc.description.affiliationDepartment of Surgery and Anatomy Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo (FMRP-USP)
dc.description.affiliationDepartment of Surgery and Anatomy FMRP-USP
dc.description.affiliationDepartment of Surgery and Anatomy Surgical Clinic Program FMRP-USP
dc.description.affiliationStructural and Functional Interactions in Rehabiliattion Universidade de Marília (UNIMAR)
dc.description.affiliationSchool of Medicine Universidade de Ribeirão Preto (UNAERP)
dc.description.affiliationFaculdade de Taquaritinga (FTGA)
dc.description.affiliationUNAERP
dc.description.affiliationDepartment of Bioscience Universidade Estadual Paulista (UNESP)
dc.description.affiliationUnespDepartment of Bioscience Universidade Estadual Paulista (UNESP)
dc.format.extent1-8
dc.identifierhttp://dx.doi.org/10.1590/s0102-865020200030000005
dc.identifier.citationActa Cirurgica Brasileira, v. 35, n. 3, p. 1-8, 2020.
dc.identifier.doi10.1590/s0102-865020200030000005
dc.identifier.fileS0102-86502020000300205.pdf
dc.identifier.issn1678-2674
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502020000300205
dc.identifier.scopus2-s2.0-85086319766
dc.identifier.urihttp://hdl.handle.net/11449/201862
dc.language.isoeng
dc.relation.ispartofActa Cirurgica Brasileira
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectApoptosis
dc.subjectErectile Dysfunction
dc.subjectEthanol
dc.subjectMicroRNAs
dc.subjectRats
dc.titleMorphological and molecular analysis of apoptosis in the corpus cavernosum of rats submitted to a chronic alcoholism model1en
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes0803250891981967[12]
unesp.author.orcid0000-0002-0837-9612[12]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentAnatomia - IBBpt

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