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Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?

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dc.contributor.authorMourao, Aline A.
dc.contributor.authorMoreira, Marina C. S.
dc.contributor.authorMelo, Aryanne B. S.
dc.contributor.authorLopes, Paulo R.
dc.contributor.authorRebelo, Ana C. S.
dc.contributor.authorRosa, Daniel A.
dc.contributor.authorFreiria-Oliveira, Andre H.
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.authorPedrino, Gustavo R.
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-27T11:13:21Z
dc.date.available2018-11-27T11:13:21Z
dc.date.issued2016-02-01
dc.description.abstractThe present study sought to determine the involvement of median preoptic nucleus (MnPO) in the regulation of the cardiovascular function and renal sympathetic activity in normotensive (NT) and spontaneously hypertensive rats (SHR). MnPO inhibition evoked by Muscimol (4 mM) nanoinjections, elicited fall in MAP and renal sympathoinhibition in NT-rats. Surprisingly, in SHRs these responses were greater than in NT-rats. These results demonstrated, for the first time that MnPO was involved in the tonic control of sympathetic activity in NT and SHRs. Furthermore, our data suggest the MnPO involvement in the increased sympathetic outflow and consequent arterial hypertension observed in SHRs. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Goias, Inst Biol Sci, Dept Physiol Sci, Ctr Neurosci & Cardiovasc Res, BR-74001970 Goiania, Go, Brazil
dc.description.affiliationUniv Fed Goias, Inst Biol Sci, Dept Morphol, BR-74001970 Goiania, Go, Brazil
dc.description.affiliationSao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Sao Paulo, Brazil
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Goias (FAPEG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFundacao de Amparo a Pesquisa do Estado de Goias (FAPEG): 2012/0055431086
dc.description.sponsorshipIdFundacao de Amparo a Pesquisa do Estado de Goias (FAPEG): 2009/10267000352
dc.description.sponsorshipIdCNPq: 483411/2012-4
dc.description.sponsorshipIdCNPq: 447496/2014-0
dc.format.extent29-33
dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2016.02.008
dc.identifier.citationAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier Science Bv, v. 195, p. 29-33, 2016.
dc.identifier.doi10.1016/j.autneu.2016.02.008
dc.identifier.fileWOS000372762800006.pdf
dc.identifier.issn1566-0702
dc.identifier.urihttp://hdl.handle.net/11449/165114
dc.identifier.wosWOS:000372762800006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAutonomic Neuroscience-basic & Clinical
dc.relation.ispartofsjr0,902
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectArterial pressure
dc.subjectHypertension
dc.subjectMnPO
dc.subjectRenal sympathetic nerve activity
dc.subjectSHR
dc.titleDoes the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes4544450092427426[8]
unesp.author.orcid0000-0002-1395-4036[8]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

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Araraquara - FOAR - Faculdade de Odontologia