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Publicação:
Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid

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dc.contributor.authorde Almeida, Amanda Cosmo [UNESP]
dc.contributor.authorFerreira, Patrícia Osório [UNESP]
dc.contributor.authorTorquetti, Carolina [UNESP]
dc.contributor.authorEkawa, Bruno [UNESP]
dc.contributor.authorCarvalho, Ana Carina Sobral [UNESP]
dc.contributor.authordos Santos, Everton Carvalho [UNESP]
dc.contributor.authorCaires, Flávio Junior [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T00:59:53Z
dc.date.available2020-12-12T00:59:53Z
dc.date.issued2020-06-01
dc.description.abstractNovel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams.en
dc.description.affiliationInstitute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationSchool of Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Sciences São Paulo State University (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 2013/09022-7
dc.description.sponsorshipIdFAPESP: 2017/14936-9
dc.description.sponsorshipIdFAPESP: 2018/12463-9
dc.description.sponsorshipIdFAPESP: 2018/24378-6
dc.format.extent2293-2303
dc.identifierhttp://dx.doi.org/10.1007/s10973-019-08958-3
dc.identifier.citationJournal of Thermal Analysis and Calorimetry, v. 140, n. 5, p. 2293-2303, 2020.
dc.identifier.doi10.1007/s10973-019-08958-3
dc.identifier.issn1588-2926
dc.identifier.issn1388-6150
dc.identifier.scopus2-s2.0-85074838952
dc.identifier.urihttp://hdl.handle.net/11449/198126
dc.language.isoeng
dc.relation.ispartofJournal of Thermal Analysis and Calorimetry
dc.sourceScopus
dc.subjectCiprofloxacin
dc.subjectCocrystal
dc.subjectMechanochemical synthesis
dc.subjectThermal analysis
dc.titleMechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic aciden
dc.typeArtigopt
dspace.entity.typePublication
unesp.author.orcid0000-0003-3187-2111[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências, Baurupt

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Araraquara - IQAR - Instituto de Química
Bauru - FC - Faculdade de Ciências