A simple algorithm for selecting cases to investigate acute and early HIV infections in low- and middle-income countries
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We documented the outcome of an over 10-year (2011–2021) effort to diagnose acute and early HIV infections (AEHI) in an Infectious Diseases Outpatient Clinic with limited resources. Of a total of 132, 119 HIV-RNA tests were performed from 2017 to 2020, 12 cases were identified, using a simple algorithm: risk exposure of 6 weeks or less before the visit and/or symptoms compatible with acute retroviral syndrome 7–30 days after exposure and/or undetermined 3rd generation rapid diagnostic test or serology. AEHI diagnoses varied from 2.4% among asymptomatic to 25% for undetermined serology cases using this simple screening applicable to different settings.
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acute HIV infection, diagnosis, HIV-1, rapid diagnostic test, viral load
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Journal of Medical Virology, v. 94, n. 2, p. 791-794, 2022.
