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Correlação entre função sistólica e presença de miofibroblastos na cardiomiopatia induzida pela doxorrubicina

dc.contributor.authorGava, Fábio Nelson
dc.contributor.authorda Silva, Sheila Nogueira Saraiva [UNESP]
dc.contributor.authorRosa, Fernando Azadinho [UNESP]
dc.contributor.authorOrtiz, Edna Mireya Gómez [UNESP]
dc.contributor.authorRodrigues, Bruno Cristian [UNESP]
dc.contributor.authorBandarra, Márcio de Barros
dc.contributor.authorVasconcelos, Rosemeri de Oliveira [UNESP]
dc.contributor.authorCamacho, Aparecido Antonio [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.date.accessioned2018-12-11T17:28:53Z
dc.date.available2018-12-11T17:28:53Z
dc.date.issued2016-09-01
dc.description.abstractCardiotoxicity induced by doroxubicin generates systolic disfunction and myocardial remodeling with presence of myofibroblasts. These cells are thought to be attracted to the injured heart to avoid the development of congestive heart failure. The objective of this study was to evaluate the systolic dysfunction generated by doxorubicin through Doppler echocardiography, and its correlation with the presence of myofibroblasts in the myocardium. Twenty-five New Zealand White rabbits were divided into two groups (control, and treated with doxorubicin). The drug was administered for six weeks; Doppler echocardiography was performed before the first, and after the last administration of doxorubicin. Immuno detection of myofibroblasts was performed by immunohistochemistry. The treated group exhibited significant reduction in systolic function as assessed by Doppler echocardiography, and increased frequency of myofibroblasts, which were present in similar amounts in the left ventricle, interventricular septum, and right ventricle. There was a significant negative correlation between number of myofibroblasts in the interventricular septum and in the left ventricle with systolic function indices, which reveals that the higher the number of fibroblasts, the worst systolic function is in rabbits treated with doxorubicin. Increase in myofibroblast numbers was not sufficient to preserve systolic function.en
dc.description.affiliationFaculdade de Medicina de Ribeirão Preto Universidade de São Paulo (USP), Av. Bandeirantes, 3900
dc.description.affiliationFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista (UNESP)
dc.description.affiliationUniversidade Federal de Uberlândia (UFU)
dc.description.affiliationUnespFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista (UNESP)
dc.format.extent1642-1648
dc.identifierhttp://dx.doi.org/10.1590/0103-8478cr20151062
dc.identifier.citationCiencia Rural, v. 46, n. 9, p. 1642-1648, 2016.
dc.identifier.doi10.1590/0103-8478cr20151062
dc.identifier.fileS0103-84782016000901642.pdf
dc.identifier.issn1678-4596
dc.identifier.issn0103-8478
dc.identifier.scieloS0103-84782016000901642
dc.identifier.scopus2-s2.0-84977469672
dc.identifier.urihttp://hdl.handle.net/11449/178126
dc.language.isoeng
dc.relation.ispartofCiencia Rural
dc.relation.ispartofsjr0,337
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDoppler echocardiography
dc.subjectDoxorubicin
dc.subjectRabbits
dc.subjectα-SMA
dc.titleCorrelação entre função sistólica e presença de miofibroblastos na cardiomiopatia induzida pela doxorrubicinapt
dc.title.alternativeCorrelation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathyen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes9642688764978907[8]
unesp.author.orcid0000-0001-9802-9271[8]
unesp.departmentClínica e Cirurgia Veterinária - FCAVpt
unesp.departmentPatologia Veterinária - FCAVpt

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