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Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity

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dc.contributor.authorDa Silva, Cristiana [UNESP]
dc.contributor.authorRibeiro, Leonardo B. [UNESP]
dc.contributor.authorFuruno, Caio C. [UNESP]
dc.contributor.authorDa Cunha, Gislaine A. [UNESP]
dc.contributor.authorDe Souza, Ronan F.F. [UNESP]
dc.contributor.authorNetto, Adelino V.G. [UNESP]
dc.contributor.authorMauro, Antonio E. [UNESP]
dc.contributor.authorFrem, Regina C.G. [UNESP]
dc.contributor.authorFernandes, José A.
dc.contributor.authorAlmeida Paz, Filipe A.
dc.contributor.authorMarino, Leonardo B. [UNESP]
dc.contributor.authorPavan, Fernando R. [UNESP]
dc.contributor.authorLeite, Clarice Q.F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:57:59Z
dc.date.available2018-12-11T16:57:59Z
dc.date.issued2015-08-04
dc.description.abstractAbstract Complexes of the type trans-[PdCl<inf>2</inf>(HL)(PPh<inf>3</inf>)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh<inf>3</inf> = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and <sup>1</sup>H NMR spectroscopies. Single-crystal X-ray diffraction determination on 3·0.9 CHCl<inf>3</inf> and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 ± 2.18 μM, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes.en
dc.description.affiliationDepartamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP - Univ Estadual Paulista, P.O. Box 355
dc.description.affiliationDepartment of Chemistry, Campus Universitário de Santiago, University of Aveiro
dc.description.affiliationDepartamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP - Univ Estadual Paulista, P.O. Box 502
dc.description.affiliationUnespDepartamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP - Univ Estadual Paulista, P.O. Box 355
dc.description.affiliationUnespDepartamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP - Univ Estadual Paulista, P.O. Box 502
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/15486-3
dc.description.sponsorshipIdFAPESP: PT2020
dc.description.sponsorshipIdFAPESP: SFRH/BPD/63736/2009
dc.format.extent10-16
dc.identifierhttp://dx.doi.org/10.1016/j.poly.2015.07.009
dc.identifier.citationPolyhedron, v. 100, p. 10-16.
dc.identifier.doi10.1016/j.poly.2015.07.009
dc.identifier.file2-s2.0-84938576973.pdf
dc.identifier.issn0277-5387
dc.identifier.lattes7927677053650819
dc.identifier.orcid0000-0002-0057-7964
dc.identifier.scopus2-s2.0-84938576973
dc.identifier.urihttp://hdl.handle.net/11449/171978
dc.language.isoeng
dc.relation.ispartofPolyhedron
dc.relation.ispartofsjr0,472
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectMycobacterium tuberculosis
dc.subjectPd(II) compounds
dc.subjectPyrazoles
dc.subjectSpectroscopy
dc.subjectTriphenylphosphine
dc.titlePyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activityen
dc.typeArtigopt
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
unesp.author.lattes7927677053650819[6]
unesp.author.lattes3300223970814448[7]
unesp.author.orcid0000-0002-0057-7964[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentQuímica Inorgânica - IQARpt

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Araraquara - IQAR - Instituto de Química
Araraquara - FCF - Faculdade de Ciências Farmacêuticas