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Genetic parameters and haplotype-based genome-wide association study of indicator traits for gastrointestinal parasite resistance in Santa Ines sheep

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dc.contributor.authorCosta, Karine Assis
dc.contributor.authorAraujo, André Campêlo
dc.contributor.authorFonseca, Pablo Augusto de Souza
dc.contributor.authorSilva, Hugo Teixeira
dc.contributor.authorMenegatto, Leonardo Sartori
dc.contributor.authorde Freitas, Luara Afonso
dc.contributor.authorCardoso, Cleyce Maiara
dc.contributor.authorCarvalho Filho, Ivan [UNESP]
dc.contributor.authorOtto, Pamela Itajara
dc.contributor.authorCosta, Ricardo Lopes Dias da
dc.contributor.authorStafuzza, Nedenia Bonvino
dc.contributor.authorPaz, Claudia Cristina Paro de
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)pt
dc.date.accessioned2026-07-20T19:47:20Z
dc.date.issued2025-05-08
dc.description.abstractGenetic parameters are of great importance in animal breeding since they determine the strategies necessary to increase the genetic progress in economic traits, for example indicator traits for resistance to endoparasites in sheep. Furthermore, genetic markers have been used to identify genomic regions associated with economically important traits, which can help increase the genetic response through genomic selection. Therefore, this study aimed to estimate genetic parameters and perform a haplotype-based genome wide association study (GWAS) to identify genomic regions associated with indicator traits for endoparasite resistance in Santa Ines sheep. Haplotype GWAS was performed using linkage disequilibrium blocks (haploblocks) defined by the Haploview software. Records from 1725 animals for Famacha© (FAM, N = 5560), packed cell volume (PCV, N = 5135), total plasma protein (TPP, N = 4356), and fecal egg count (FEC, N = 4248) were used for analysis. The pedigree file contained information from 4821 animals; of these, 638 animals were genotyped using the Ovine SNP50 Genotyping BeadChip. Heritability estimates were moderate for FAM (0.26), PCV (0.26), TPP (0.16), and log-transformed FEC (0.19). Genomic regions that explained more than 0.3 % of the total additive genetic variance of the traits were defined as significant. These regions overlapped with quantitative traits loci associated with eosinophil number, fecal egg count, hematocrit, and immunoglobulin levels. In the top regions for the traits evaluated we found genes individually involved in inflammatory response, immunity, macrophage function in host-pathogen interactions, and other biological functions. All indicator traits for resistance to gastrointestinal parasites evaluated in this study exhibited sufficient genetic variability to respond to selection and can be used to improve the health and consequently the production of Santa Ines sheep.
dc.description.affiliationBeef Cattle Research Center, Animal Science Institute, Sertãozinho 14174-000, Brazil. Electronic address: karineacosta90@gmail.com.
dc.description.affiliationDepartment of Animal Science, Purdue University, West Lafayette 47906, USA. Electronic address: araujoa@purdue.edu.
dc.description.affiliationCentre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph N1G 2W1, Canada. Electronic address: pfonseca@uoguelph.ca.
dc.description.affiliationDepartment of Animal Science, Federal University of Viçosa, Viçosa 36570-900, Brazil. Electronic address: hugots.silva@gmail.com.
dc.description.affiliationDepartment of Genetics, Ribeirão Preto Medical School (FMRP), University of São Paulo (USP), Ribeirão Preto 14049-900, Brazil. Electronic address: leonardomenegatto@gmail.com.
dc.description.affiliationDepartment of Genetics, Ribeirão Preto Medical School (FMRP), University of São Paulo (USP), Ribeirão Preto 14049-900, Brazil. Electronic address: luaraa.freitas@gmail.com.
dc.description.affiliationBeef Cattle Research Center, Animal Science Institute, Sertãozinho 14174-000, Brazil. Electronic address: cleycecardosozoo@gmail.com.
dc.description.affiliationSchool of Agricultural and Veterinarian Sciences, São Paulo State University (UNESP), Jaboticabal 14884-900, Brazil. Electronic address: ivancf08@gmail.com.
dc.description.affiliationDepartment of Animal Science, University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil. Electronic address: ottopamela90@gmail.com.
dc.description.affiliationSão Paulo Agency of Agribusiness and Technology, Animal Science Institute, Nova Odessa 13380-011, Brazil. Electronic address: rldcosta@sp.gov.br.
dc.description.affiliationBeef Cattle Research Center, Animal Science Institute, Sertãozinho 14174-000, Brazil. Electronic address: nedeniabs@gmail.com.
dc.description.affiliationDepartment of Genetics, Ribeirão Preto Medical School (FMRP), University of São Paulo (USP), Ribeirão Preto 14049-900, Brazil; Sustainable Livestock Research Center, Animal Science Institute, São José do Rio Preto 15130-000, Brazil. Electronic address: claudiacristinaparopaz@gmail.com.
dc.description.affiliationUnespSchool of Agricultural and Veterinarian Sciences, São Paulo State University (UNESP), Jaboticabal 14884-900, Brazil. Electronic address: ivancf08@gmail.com.
dc.identifierhttps://app.dimensions.ai/details/publication/pub.1188505110
dc.identifier.dimensionspub.1188505110
dc.identifier.doi10.1016/j.vetpar.2025.110498
dc.identifier.issn0304-4017
dc.identifier.issn1873-2550
dc.identifier.orcid0000-0001-6227-4670
dc.identifier.orcid0000-0002-8057-472X
dc.identifier.orcid0000-0002-6917-7475
dc.identifier.orcid0000-0002-3473-2061
dc.identifier.orcid0000-0002-5027-6449
dc.identifier.orcid0000-0001-9675-8999
dc.identifier.orcid0000-0003-1702-4626
dc.identifier.orcid0000-0001-8888-6915
dc.identifier.orcid0000-0001-6432-2330
dc.identifier.orcid0000-0002-7267-4552
dc.identifier.pmid40359809
dc.identifier.urihttps://hdl.handle.net/11449/328239
dc.publisherElsevier
dc.relation.ispartofVeterinary Parasitology; v. 337; p. 110498
dc.rights.accessRightsAcesso restritopt
dc.rights.sourceRightsclosed
dc.sourceDimensions
dc.titleGenetic parameters and haplotype-based genome-wide association study of indicator traits for gastrointestinal parasite resistance in Santa Ines sheep
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication3d807254-e442-45e5-a80b-0f6bf3a26e48
relation.isOrgUnitOfPublication.latestForDiscovery3d807254-e442-45e5-a80b-0f6bf3a26e48
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias