Publication: Behavioral effects of acute exposure to the insecticide fipronil
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Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
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Volume Title
Publisher
Academic Press Inc. Elsevier B.V.
Type
Article
Access right
Acesso aberto
Abstract
The effects of fipronil (Frontline (R) Top Spot) were investigated in 40 days old rats utilizing open field (OF), hole-board (HB) and elevated plus-maze (EPM) apparatus. Rats (N=15) received topical application of fipronil (70, 140 and 280 mg/kg) in the neck region and behavior was tested 3 h after administration. Animals treated with corn oil (vehicle) were used as controls. In the of test animals treated with fipronil at 140 mg/kg showed increased rearing, whereas animals exposed to 280 mg/kg showed increased freezing, grooming, and rearing. In the HB test fipronil at 280 mg/kg increased head-dip and head-dipping behaviors. In the EPM test the only observed effect was increased number of entries in both open and closed EPM arms in animals treated with 280 mg/kg. In conclusion, dermal exposure to fipronil causes effects related to emotionality, fear, and exploratory activity; results add strength to the growing concern that pirazole insecticides can be neurotoxic to humans. Published by Elsevier B.V.
Description
Keywords
Fipronil insecticide, Behavior, Open-field, Hole-board, Elevated plus-maze, Neurotoxicity, Rat
Language
English
Citation
Pesticide Biochemistry and Physiology. San Diego: Academic Press Inc. Elsevier B.V., v. 99, n. 3, p. 221-225, 2011.
