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Cereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3

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dc.contributor.authorPavan, Aline R. [UNESP]
dc.contributor.authorSmalley, Joshua P.
dc.contributor.authorPatel, Urvashi
dc.contributor.authorPytel, Wiktoria A.
dc.contributor.authordos Santos, Jean Leandro [UNESP]
dc.contributor.authorCowley, Shaun M.
dc.contributor.authorSchwabe, John W. R.
dc.contributor.authorHodgkinson, James T.
dc.contributor.institutionUniversity of Leicester
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2025-04-29T18:38:10Z
dc.date.issued2024-11-05
dc.description.abstractHistone deacetylase (HDAC) enzymes 1-3 exist in several corepressor complexes and are viable drug targets. To date, proteolysis targeting chimeras (PROTACs) designed to target HDAC1-3 typically exhibit the selective degradation of HDAC3. Herein, we report cereblon-recruiting PROTACs that degrade HDAC1 with selectivity over HDAC3.en
dc.description.affiliationLeicester Institute of Structural and Chemical Biology School of Chemistry University of Leicester, University Road
dc.description.affiliationSão Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationA Department of Molecular and Cell Biology University of Leicester
dc.description.affiliationLeicester Institute of Structural and Chemical Biology Department of Molecular and Cell Biology University of Leicester
dc.description.affiliationInstitute of Chemistry Sa˜o Paulo State University (UNESP)
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationUnespInstitute of Chemistry Sa˜o Paulo State University (UNESP)
dc.format.extent13879-13882
dc.identifierhttp://dx.doi.org/10.1039/d4cc05138f
dc.identifier.citationChemical Communications, v. 60, n. 94, p. 13879-13882, 2024.
dc.identifier.doi10.1039/d4cc05138f
dc.identifier.issn1364-548X
dc.identifier.issn1359-7345
dc.identifier.scopus2-s2.0-85209124850
dc.identifier.urihttps://hdl.handle.net/11449/298799
dc.language.isoeng
dc.relation.ispartofChemical Communications
dc.sourceScopus
dc.titleCereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3en
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.orcid0000-0002-2460-2829[5]
unesp.author.orcid0000-0001-9978-7322[8]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas
Araraquara - IQAR - Instituto de Química