Assessment of vitamin A status in chronic obstructive pulmonary disease patients and healthy smokers
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The relation between vitamin A status and the degree of lung airway obstruction was examined in a cross-sectional study of 36 male subjects aged 43-74 y who were assigned to five groups as follows: healthy nonsmokers (n = 7), healthy smokers (n = 7), mild chronic obstructive pulmonary disease (COPD-mild) patients (n = 9), COPD-moderate-severe patients (n = 7), and COPD-moderate-severe patients with exacerbation (+ex; n = 6). Smoking habits, pulmonary function tests, and energy-protein status were assessed; serum concentrations of retinyl esters, retinol, retinol binding protein, and transthyretin and relative dose responses were measured. In addition, 12 male smokers aged 45-61 y with mild COPD were randomly assigned to two groups for a longitudinal study: six subjects consumed vitamin A (1000 RE/d; COPD- vitamin A) and six subjects received placebo for 30 d. Lowered serum retinol concentrations were found in the COPD-moderate-severe and COPD-moderate- severe+ex groups. Measurements of vitamin A status in healthy smokers and in COPD-mild patients were not different from those in healthy nonsmokers. The improvement of pulmonary function test results after vitamin A supplementation [mean increase for 1-s forced expiratory volume (FEV1) = 22.9% in the COPD-vitamin A group] may support the assumption of a local (respiratory) vitamin A deficiency in patients with this disease.
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chronic obstructive pulmonary disease , pulmonary function tests , retinol circulating complex , Vitamin A status assessment , acute phase protein , albumin , alpha carotene , beta carotene , c reactive protein , ceruloplasmin , placebo , prealbumin , retinol binding protein , retinol ester , retinol palmitate , airway obstruction , chronic obstructive lung disease , cigarette smoking , clinical protocol , clinical trial , controlled clinical trial , controlled study , diet supplementation , disease severity , forced expiratory volume , lung function test , nutritional status , oral drug administration , randomized controlled trial , retinol deficiency , vitamin blood level , Analysis of Variance , Carotenoids , Cross-Sectional Studies , Diet , Intestinal Absorption , Liver , Longitudinal Studies , Lung , Lung Diseases, Obstructive , Middle Aged , Nutritional Status , Respiratory Function Tests , Smoking , Vitamin A , Vitamin A Deficiency
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Inglês
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American Journal of Clinical Nutrition, v. 64, n. 6, p. 928-934, 1996.
