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SARS-COV-2 genomic monitoring in the state of São Paulo unveils two emerging AY.43 sublineages

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dc.contributor.authorLima, Alex Ranieri Jerônimo
dc.contributor.authorRibeiro, Gabriela
dc.contributor.authorViala, Vincent Louis
dc.contributor.authorde Lima, Loyze Paola Oliveira
dc.contributor.authorMartins, Antonio Jorge
dc.contributor.authorBarros, Claudia Renata dos Santos
dc.contributor.authorMarqueze, Elaine Cristina
dc.contributor.authorBernardino, Jardelina de Souza Todao
dc.contributor.authorMoretti, Debora Botequio
dc.contributor.authorRodrigues, Evandra Strazza
dc.contributor.authorSantos, Elaine Vieira
dc.contributor.authorBrassaloti, Ricardo Augusto
dc.contributor.authorCassano, Raquel de Lello Rocha Campos
dc.contributor.authorMariani, Pilar Drummond Sampaio Corrêa
dc.contributor.authorClemente, Luan Gaspar
dc.contributor.authorAssato, Patricia Akemi [UNESP]
dc.contributor.authorCosta, Felipe Allan da Silva da [UNESP]
dc.contributor.authorPoleti, Mirele Daiana
dc.contributor.authorLesbon, Jessika Cristina Chagas
dc.contributor.authorMattos, Elisangela Chicaroni
dc.contributor.authorBanho, Cecilia Artico
dc.contributor.authorSacchetto, Lívia
dc.contributor.authorMoraes, Marília Mazzi
dc.contributor.authorPalmieri, Melissa
dc.contributor.authorMartininghi, Maiara
dc.contributor.authorCaldeira, Luiz Artur Vieira
dc.contributor.authorSilva, Fabiana Erica Vilanova da
dc.contributor.authorGrotto, Rejane Maria Tommasini [UNESP]
dc.contributor.authorSouza-Neto, Jayme A. [UNESP]
dc.contributor.authorGiovanetti, Marta
dc.contributor.authorJunior Alcantara, Luiz Carlos
dc.contributor.authorNogueira, Maurício Lacerda
dc.contributor.authorFukumasu, Heidge
dc.contributor.authorCoutinho, Luiz Lehmann
dc.contributor.authorKashima, Simone
dc.contributor.authorNeto, Raul Machado
dc.contributor.authorCovas, Dimas Tadeu
dc.contributor.authorSlavov, Svetoslav Nanev
dc.contributor.authorSampaio, Sandra Coccuzzo
dc.contributor.authorElias, Maria Carolina
dc.contributor.institutionButantan Institute
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionNGS Soluções Genômicas
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionSão José do Rio Preto
dc.contributor.institutionCoordenação de Vigilância em Saúde—Secretaria Municipal da Saúde
dc.contributor.institutionSecretaria Municipal da Saúde
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionFIOCRUZ
dc.date.accessioned2022-04-28T19:51:31Z
dc.date.available2022-04-28T19:51:31Z
dc.date.issued2022-01-01
dc.description.abstractDelta VOC is highly diverse with more than 120 sublineages already described as of November 30, 2021. In this study, through active monitoring of circulating severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants in the state of São Paulo, southeast Brazil, we identified two emerging sublineages from the ancestral AY.43 strain which were classified as AY.43.1 and AY.43.2. These sublineages were defined by the following characteristic nonsynonymous mutations ORF1ab:A4133V and ORF3a:T14I for the AY.43.1 and ORF1ab:G1155C for the AY.43.2 and our analysis reveals that they might have a likely-Brazilian origin. Much is still unknown regarding their dissemination in the state of São Paulo and Brazil as well as their potential impact on the ongoing vaccination process. However, the results obtained in this study reinforce the importance of genomic surveillance activity for timely identification of emerging SARS-CoV-2 variants which can impact the ongoing SARS-CoV-2 vaccination and public health policies.en
dc.description.affiliationCenter of Scientific Development Butantan Institute, São Paulo
dc.description.affiliationBlood Center of Ribeirão Preto Ribeirão Preto Medical School University of São Paulo, São Paulo
dc.description.affiliationCentro de Genômica Funcional da ESALQ University of São Paulo, São Paulo
dc.description.affiliationNGS Soluções Genômicas, São Paulo
dc.description.affiliationDepartment of Bioprocesses and Biotechnology School of Agricultural Sciences São Paulo State University (UNESP), São Paulo
dc.description.affiliationDepartment of Veterinary Medicine School of Animal Science and Food Engineering University of São Paulo, São Paulo
dc.description.affiliationMedicine School of São José do Rio Preto (FAMERP) São José do Rio Preto, São Paulo
dc.description.affiliationCoordenação de Vigilância em Saúde—Secretaria Municipal da Saúde, São Paulo
dc.description.affiliationSecretaria Municipal da Saúde, São Paulo
dc.description.affiliationMolecular Biology Laboratory Applied Biotechnology Laboratory Clinical Hospital of the Botucatu Medical School, São Paulo
dc.description.affiliationLaboratório de Genética Celular e Molecular Instituto de Ciências Biológicas Universidade Federal de Minas Gerais, Minas Gerais
dc.description.affiliationLaboratório de Flavivírus Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro
dc.description.affiliationUnespDepartment of Bioprocesses and Biotechnology School of Agricultural Sciences São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespMolecular Biology Laboratory Applied Biotechnology Laboratory Clinical Hospital of the Botucatu Medical School, São Paulo
dc.identifierhttp://dx.doi.org/10.1002/jmv.27674
dc.identifier.citationJournal of Medical Virology.
dc.identifier.doi10.1002/jmv.27674
dc.identifier.issn1096-9071
dc.identifier.issn0146-6615
dc.identifier.scopus2-s2.0-85125997787
dc.identifier.urihttp://hdl.handle.net/11449/223588
dc.language.isoeng
dc.relation.ispartofJournal of Medical Virology
dc.sourceScopus
dc.subjectAY.43
dc.subjectDelta VOC
dc.subjectemerging sublineages
dc.subjectgenomic surveillance
dc.subjectSARS-CoV-2
dc.titleSARS-COV-2 genomic monitoring in the state of São Paulo unveils two emerging AY.43 sublineagesen
dc.typeArtigopt
dspace.entity.typePublication
unesp.author.orcid0000-0003-1102-2419[32]
unesp.author.orcid0000-0002-1487-0141[35]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt

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Botucatu - FMB - Faculdade de Medicina