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Cholinergic responses of seminal vesicles isolated from rats exposed perinatally to hydrocortisone

dc.contributor.authorPereira, OCM
dc.contributor.authorYasuhara, F.
dc.contributor.authorArena, A. C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:48:59Z
dc.date.available2014-05-20T13:48:59Z
dc.date.issued2003-07-01
dc.description.abstractThis study was performed in order to investigate the cholinomimetic response of seminal vesicles isolated from rats treated with hydrocortisone acetate during perinatal life. At the adult phase, the body weight and the wet weight of the seminal vesicle of these animals were unchanged. However, these male rats exhibited a significant reduction in plasma testosterone concentration. A significant increase in the sensitivity of the seminal vesicle to acetylcholine was also observed. Despite this, there was a significant reduction in the maximum contractile response of the organ to this transmitter. These results indicate that exposure to hydrocortisone during the critical period of brain sexual differentiation has a long-term effect on testosterone production of male rats. In addition, physiological levels of cortisone in perinatal life are also essential to support the contractile response pattern of the seminal vesicle to acetylcholine in adult life, probably crucial to the reproductive process. (C) 2003 Elsevier B.V. Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Inst Biosci, Dept Pharmacol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Inst Biosci, Dept Pharmacol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent91-95
dc.identifierhttp://dx.doi.org/10.1016/S1043-6618(03)00061-6
dc.identifier.citationPharmacological Research. London: Academic Press Ltd Elsevier B.V. Ltd, v. 48, n. 1, p. 91-95, 2003.
dc.identifier.doi10.1016/S1043-6618(03)00061-6
dc.identifier.issn1043-6618
dc.identifier.lattes0729220781785349
dc.identifier.urihttp://hdl.handle.net/11449/17436
dc.identifier.wosWOS:000183687300013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacological Research
dc.relation.ispartofjcr4.897
dc.relation.ispartofsjr1,811
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecthydrocortisonept
dc.subjectacetylcholinept
dc.subjectacetyl-beta-methylcholinept
dc.subjectseminal vesiclept
dc.subjectratpt
dc.titleCholinergic responses of seminal vesicles isolated from rats exposed perinatally to hydrocortisoneen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes0729220781785349[3]
unesp.author.orcid0000-0002-2373-9399[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFarmacologia - IBBpt

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