Publicação: Preemptive dexamethasone and etoricoxib for pain and discomfort prevention after periodontal surgery: A double-masked, crossover, controlled clinical trial
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Background: Several anti-inflammatory drugs have been used to reduce pain and discomfort after periodontal surgeries. This study evaluates the efficacy of using etoricoxib and dexamethasone for pain prevention after open-flap debridement surgery. Methods: For this prospective, double-masked, crossover, placebo-controlled, randomized clinical trial, open-flap debridement surgeries were performed on 15 patients (eight males and seven females, age range 20 to 56 years: mean age ± SD: 40 ± 9.7 years) who presented with chronic periodontitis after nonsurgical periodontal therapy at three quadrants. Each patient underwent three surgical procedures at intervals of 30 days and received one of the following premedication protocols 1-hour before surgery: group 1 = placebo, group 2 = 8 mg dexamethasone, and group 3 = 120 mg etoricoxib. Rescue medication (750 mg acetaminophen) was given to each patient who was instructed to take it when necessary. Pain intensity and discomfort were evaluated by a 101-point numeric rate scale and a four-point verbal rate scale, respectively, hourly for the first 8 hours after surgery and three times a day on the following 3 days. Results: The results demonstrate that groups 2 and 3 present reduced postoperative pain-intensity levels compared to group 1. There were statistically significant differences at the 4, 5, 6, 7, and 8 hour-periods after surgery (Friedman test; P<0.05). Furthermore, rescue-medication intake was significantly lower for groups 2 and 3 than for group 1 (analysis of variance; P<0.02). Conclusion: The adoption of a preemptive medication protocol using etoricoxib or dexamethasone may be considered effective for pain and discomfort prevention after open-flap debridement surgeries.
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Analgesia, Dexamethasone, Etoricoxib, Pain, Pain measurement, Preanesthetic medication, analgesic agent, antiinflammatory agent, cyclooxygenase 2 inhibitor, dexamethasone, etoricoxib, glucocorticoid, paracetamol, placebo, pyridine derivative, sulfone, adolescent, adult, chronic periodontitis, clinical trial, comparative study, controlled clinical trial, controlled study, crossover procedure, dental anxiety, double blind procedure, female, follow up, human, male, middle aged, pain assessment, plastic surgery, postoperative pain, premedication, prospective study, psychological aspect, randomized controlled trial, sex difference, treatment outcome, Acetaminophen, Adolescent, Adult, Analgesics, Non-Narcotic, Anti-Inflammatory Agents, Chronic Periodontitis, Cross-Over Studies, Cyclooxygenase 2 Inhibitors, Dental Anxiety, Double-Blind Method, Female, Follow-Up Studies, Glucocorticoids, Humans, Male, Middle Aged, Pain Measurement, Pain, Postoperative, Placebos, Premedication, Prospective Studies, Pyridines, Sex Factors, Sulfones, Surgical Flaps, Treatment Outcome, Young Adult
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Inglês
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Journal of Periodontology, v. 81, n. 8, p. 1153-1160, 2010.
