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Mechanism of anticlastogenicity of Agaricus blazei Murill mushroom organic extracts in wild type CHO (K-1) and repair deficient (xrs5) cells by chromosome aberration and sister chromatid exchange assays

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dc.contributor.authorLuiz, R. C.
dc.contributor.authorJordao, B. Q.
dc.contributor.authorda Eira, A. F.
dc.contributor.authorRibeiro, L. R.
dc.contributor.authorMantovani, M. S.
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Luterana Brasil
dc.date.accessioned2014-05-20T13:19:46Z
dc.date.available2014-05-20T13:19:46Z
dc.date.issued2003-07-25
dc.description.abstractAgaricus blazei Murill is a medicinal mushroom native to Brazil. The present work assessed the clastogenic and anticlastogenic potential of organic extracts (ethanol and chloroform/methanol) from the lineage AB97/11 in chinese hamster CHO-K-1 (wild type) and CHO-xrs5 (repair deficient) cells using the chromosome aberration (CA) and sister chromatid exchange (SCE) assays. In these experimental conditions were observed: (a) anticlastogenic effect at concentrations of 0.06 and 0.09% of the EtOH extract and at the 0.03 and 0.06% concentrations of the C/MetOH extract in CHO-K-1; (b) absence of protector effect on CHO-xrs5 cells; and (c) absence of protector effect in the SCE assay. These results indicate that organic extracts of A. blazei lineage AB97/11 present bio-antimutagenic type protective activity. (C) 2003 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Londrina, Ctr Ciências Biol, Dept Biol Geral, BR-86051990 Londrina, PR, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Ciências Agron, Dept Prod Vegetal Modulo Cogumelos, Botucatu, SP, Brazil
dc.description.affiliationUniv Luterana Brasil, ULBRA, Luterana, RS, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Ciências Agron, Dept Prod Vegetal Modulo Cogumelos, Botucatu, SP, Brazil
dc.format.extent75-79
dc.identifierhttp://dx.doi.org/10.1016/S0027-5107(03)00098-8
dc.identifier.citationMutation Research-fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier B.V., v. 528, n. 1-2, p. 75-79, 2003.
dc.identifier.doi10.1016/S0027-5107(03)00098-8
dc.identifier.issn0027-5107
dc.identifier.urihttp://hdl.handle.net/11449/5296
dc.identifier.wosWOS:000184535200008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMutation Research: Fundamental and Molecular Mechanisms of Mutagenesis
dc.relation.ispartofjcr2.398
dc.relation.ispartofsjr0,111
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAgaricus blazei Murrilpt
dc.subjectchromosome aberration assaypt
dc.subjectsister chromatid exchange assaypt
dc.subjectCHO cellspt
dc.subjectmethyl methanesulphonatept
dc.titleMechanism of anticlastogenicity of Agaricus blazei Murill mushroom organic extracts in wild type CHO (K-1) and repair deficient (xrs5) cells by chromosome aberration and sister chromatid exchange assaysen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.orcid0000-0003-1107-4809[1]
unesp.author.orcid0000-0001-5268-6508[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agronômicas, Botucatupt
unesp.departmentProdução e Melhoramento Vegetal - FCApt
unesp.departmentProteção Vegetal - FCApt

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Botucatu - FCA - Faculdade de Ciências Agronômicas