Publicação: Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release
Carregando...
Arquivos
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Univ Fed Sao Carlos, Dept Engenharia Materials
Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
In this paper, a novel wound dressing membrane for controlled release of gentamicin (GE), while covering and protecting the wound was investigated. Chitosan (CHI) was associated with methoxy polyethylene glycol - polycaprolactone copolymer (mPEG-PCL) to prepare the blended wound dressing membranes. The use of copolymer mPEG-PCL was necessary to improve the compatibility between CHI and PCL. The association of CHI and PCL was required to control the water retention and release rate of encapsulated GE. In vitro release studies were performed with the mPEG-PCL/ CHI-GE membranes in order to evaluate the effect of copolymer concentration on the kinetics of GE release and water uptake. Reduced burst release rates and swelling ratios were observed for the 1/2 and 1/4 mPEG-PCL/CHI-GE membranes. In addition, all gentamicin-loaded membranes inhibited S. aureus and E. coli growth, and demonstrated color, moisture and thermal stability. Therefore, mPEG-PCL/CHI-GE membranes showed important features for potential wound dressing and drug delivery applications.
Descrição
Palavras-chave
Copolymer, blend, methoxy polyethylene glycol, polycaprolactone, antibiotic, drug delivery
Idioma
Inglês
Como citar
Materials Research-ibero-american Journal Of Materials. Sao Carlos: Univ Fed Sao Carlos, Dept Engenharia Materials, v. 21, n. 6, 10 p., 2018.
