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Thermal stability and thermal decomposition of the antihypertensive drug amlodipine besylate

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dc.contributor.authorSilva, A. C. M. [UNESP]
dc.contributor.authorGalico, D. A. [UNESP]
dc.contributor.authorGuerra, R. B. [UNESP]
dc.contributor.authorPerpetuo, G. L. [UNESP]
dc.contributor.authorLegendre, A. O. [UNESP]
dc.contributor.authorRinaldo, D. [UNESP]
dc.contributor.authorBannach, G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-22T07:20:59Z
dc.date.available2015-10-22T07:20:59Z
dc.date.issued2015-04-01
dc.description.abstractSimultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC) and coupled thermogravimetry coupled to infrared spectroscopy (TG-FTIR) were used to study the antihypertensive drug amlodipine besylate. The TG-DSC curves provided information concerning the thermal stability and the decomposition steps of the compound, while the DSC technique allowed us to confirm that the melting occurs concomitantly with the decomposition of the sample. By using the TG coupled to FTIR coupled techniques, it was possible to identify ammonia and methanol and CO2 as compounds released during the thermal degradation of the drug.en
dc.description.affiliationUNESP Univ Estadual Paulista, Fac Ciencias, Dept Quim, BR-17033260 Sao Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Fac Ciencias, Dept Quim, BR-17033260 Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2012/21450-1
dc.format.extent889-892
dc.identifierhttp://link.springer.com/article/10.1007%2Fs10973-014-3992-z
dc.identifier.citationJournal Of Thermal Analysis And Calorimetry, v. 120, n. 1, p. 889-892, 2015.
dc.identifier.doi10.1007/s10973-014-3992-z
dc.identifier.issn1388-6150
dc.identifier.urihttp://hdl.handle.net/11449/129850
dc.identifier.wosWOS:000352139800097
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal Of Thermal Analysis And Calorimetry
dc.relation.ispartofjcr2.209
dc.relation.ispartofsjr0,587
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAmlodipine besylateen
dc.subjectThermal behavioren
dc.subjectTG-FTIRen
dc.titleThermal stability and thermal decomposition of the antihypertensive drug amlodipine besylateen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.lattes3123518117881050[5]
unesp.author.orcid0000-0002-2794-5763[5]
unesp.author.orcid0000-0001-5363-6481[6]
unesp.author.orcid0000-0002-8790-5069[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências, Baurupt
unesp.departmentQuímica - FCpt

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Bauru - FC - Faculdade de Ciências