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Redox-tagged peptide for capacitive diagnostic assays

dc.contributor.authorSantos, Adriano [UNESP]
dc.contributor.authorPiccoli, Julia P. [UNESP]
dc.contributor.authorFilho, Norival A.s.
dc.contributor.authorCilli, Eduardo Maffud [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-05-15T13:30:15Z
dc.date.available2015-05-15T13:30:15Z
dc.date.issued2014
dc.description.abstractEarly detection assays play a key role in the successful treatment of most diseases. Redox capacitive biosensors were recently introduced as a potential electroanalytical assay platform for point-of-care applications but alternative surfaces (besides a mixed layer containing ferrocene and antibody receptive component) for recruiting important clinical biomarkers are still needed. Aiming to develop alternative receptive surfaces for this novel electrochemical biosensing platform, we synthesized a ferrocene redoxtagged peptide capable of self-assembly into metallic interfaces, a potentially useful biological surface functionalization for bedside diagnostic assays. As a proof of concept we used C-reactive protein (CRP), as a model biomarker, and compared the obtained results to those of previously reported capacitive assays. The redox-tagged peptide approach shows a limit of detection of 0.8 nmol L 1 (same as 94 ng mL 1 ) and a linear range (R2 ∼98%) with the logarithm of the concentration of the analyte comprising 0.5–10.0 nmol L 1 , within a clinical relevant range for CRP.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Bioquímica e Tecnologia Química, Instituto de Química de Araraquara, Araraquara, Rua Professor Francisco Degni, 55, Jardim Quitandinha, CEP 14800060, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Bioquímica e Tecnologia Química, Instituto de Química de Araraquara, Araraquara, Rua Professor Francisco Degni, 55, Jardim Quitandinha, CEP 14800060, SP, Brasil
dc.format.extent281-287
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0956566314010136
dc.identifier.citationBiosensors & Bioelectronics, v. 68, p. 281-287, 2014.
dc.identifier.doi10.1016/j.bios.2014.12.059
dc.identifier.issn0956-5663
dc.identifier.lattes9424346762460416
dc.identifier.orcid0000-0002-4767-0904
dc.identifier.urihttp://hdl.handle.net/11449/123463
dc.language.isopor
dc.relation.ispartofBiosensors & Bioelectronics
dc.relation.ispartofjcr8.173
dc.relation.ispartofsjr2,373
dc.rights.accessRightsAcesso restritopt
dc.sourceCurrículo Lattes
dc.subjectElectrochemical capacitance spectroscopyen
dc.subjectFerrocene-tagged peptideen
dc.subjectLabel-free redox capacitance biosensingen
dc.subjectBinding affinity constanten
dc.titleRedox-tagged peptide for capacitive diagnostic assaysen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscoverybc74a1ce-4c4c-4dad-8378-83962d76c4fd
unesp.author.lattes9424346762460416
unesp.author.orcid0000-0002-4767-0904[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia Química - IQpt

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