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Histological analysis of the association of low level laser therapy and platelet-rich plasma in regeneration of muscle injury in rats

dc.contributor.authorGarcia, Thiago Alves
dc.contributor.authorCamargo, Regina Celi Trindade [UNESP]
dc.contributor.authorKoike, Tatiana Emy [UNESP]
dc.contributor.authorOzaki, Guilherme Akio Tamura
dc.contributor.authorCastoldi, Robson Chacon
dc.contributor.authorCamargo Filho, José Carlos Silva [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:34:53Z
dc.date.available2018-12-11T17:34:53Z
dc.date.issued2017-11-01
dc.description.abstractObjective Muscle injuries are common, and their treatment requires costs and time off. Platelet rich plasma and low level laser therapy have been shown to be affordable and easy to use. The aim of this study was to evaluate the associated effects of low level laser therapy and platelet rich plasma on the treatment of the soleus muscle injured by strain in rats. Methods Thirty-five rats were randomly allocated into five groups: Control (C), Injury Control (IC), injury PRP (IP), injury LLLT (ILT) and injury LLLT and PRP (ILTP). The strain injury was induced in the soleus muscle and the IP group received application of platelet rich plasma immediately after the lesion, while the ILT group received low level laser therapy. After seven days, all animals were euthanized and the soleus muscle removed for further histological analysis. Results The association of both treatments (ILTP) resulted in better histological aspects than the low level laser therapy and platelet rich plasma alone, when compared with the injury group (IC). The collagen analysis exhibited a significant increase in the ILT group (2.99 SD = 1.13) compared to the C (1.88 SD = 0.41, p = 0.012) and IP (2.04 SD = 0.44, p = 0.018). Conclusion The association of low level laser therapy with platelet rich plasma produced better results on muscle injury compared to the isolated use of these therapies. Furthermore, none of the treatments could modulate the collagen deposition in relation to injury group.en
dc.description.affiliationUniversidade Estadual de Campinas (UNICAMP) Programa de Pós-graduação em Ciências da Cirurgia
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Departamento de Fisioterapia
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Departamento de Fisioterapia
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2014/10086-2
dc.format.extent425-433
dc.identifierhttp://dx.doi.org/10.1016/j.bjpt.2017.06.007
dc.identifier.citationBrazilian Journal of Physical Therapy, v. 21, n. 6, p. 425-433, 2017.
dc.identifier.doi10.1016/j.bjpt.2017.06.007
dc.identifier.issn1809-9246
dc.identifier.issn1413-3555
dc.identifier.scopus2-s2.0-85034102578
dc.identifier.urihttp://hdl.handle.net/11449/179364
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Physical Therapy
dc.relation.ispartofsjr0,802
dc.relation.ispartofsjr0,802
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCollagen
dc.subjectInflammation
dc.subjectRehabilitation
dc.titleHistological analysis of the association of low level laser therapy and platelet-rich plasma in regeneration of muscle injury in ratsen
dc.typeArtigo
dspace.entity.typePublication
unesp.departmentFisioterapia - FCTpt

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