Complexos fosfínicos e suas aplicações na medicina
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Date
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Coadvisor
Graduate program
Undergraduate course
Journal Title
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Volume Title
Publisher
Soc Brasileira Quimica
Type
Review
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Acesso aberto
Abstract
Phosphines are well known to chemists. The ligands themselves are widely used in organic synthesis (e.g. The Wittig reaction) and transition metal phosphine complexes have been studied extensively primarily for their applications as hydrogenation catalysts (e.g. Wilkinson's catalyst). In this article attention is focused on the biological properties of phosphines and metal phosphine complexes since the triethylphosphine Au(I) complex, auranofin, has been used as antiarthritic drug for clinical use. This fact has provided a stimulus for exploration of the biological chemistry of phosphines and their metal complexes. Metal phosphine complexes also offer potential as heart-imaging agents and anticancer drugs.
Description
Keywords
phosphines, complexes, biological properties
Language
Portuguese
Citation
Quimica Nova. São Paulo: Soc Brasileira Quimica, v. 19, n. 6, p. 651-659, 1996.
