Comparison of the inflammatory reaction induced by facial implants os silicone and polytetrafluoroethylene. Study in rabbits

Abstract

Background and Objective. The treatment for many facial deformities uses many kinds of autologous grafts or alloplastic materials. Polytetrafluoroethylene (PTFE) has several advantages due to its hydrophobic properties, inducing less inflammatory reaction. Our study evaluates and compares the inflammatory reaction induced by silicone and PTFE stripes. Methods. Fragments of silicone and PTFE implants were placed in rabbits ears using an incision and a subcutaneous gap. The histological analysis was made 8 weeks later. The samples were stained with hematoxylin/eosin and classified as chronic inflammatory reaction graduation, the presence of neutrophils, lymphocytes, eosinophils, neoangiogenesis, fibroblasts, edema and presence of bleeding and scar. Samples to microbiological analysis and evaluation of bruise and abscess were collected at the moment of sacrifice. Results. Prevalence of abscess at sacrifice and hematoma during the first weeks were significantly higher (p>0.05) in the silicon group. Conclusions. PTFE induced as much inflammatory reaction as the silicon but with less abscess and hematoma formation.