Atividade endectocida, segurança clínica e farmacocinética de resíduos de uma nova alternativa terapêutica (Fluazuron + Abamectina) em bovinos
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Data
2010-08-26
Autores
Mendonça, Rafael Paranhos de [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
Uma formulação medicamentosa inédita contendo fluazuron 3,0% + abamectina 0,5%*, administrada via tópica “pour-on” (1ml\10kg de peso corpóreo), foi avaliada em sete experimentos, incluindo segurança clínica e farmacocinética de resíduos, destes compostos, em bovinos medicados. A inocuidade e a segurança clínica da formulação supracitada foram aferidas por exames clínicos, hemogramas e dosagens bioquímicas. Quanto à atividade carrapaticida, foram conduzidos dois ensaios, um utilizando bovinos experimentalmente infestados e outro bovinos naturalmente parasitados por Rhipicephalus (Boophilus) microplus. Em dois outros estudos, avaliou-se a eficácia contra Haematobia irritans e contra larvas de Dermatobia hominis em bovinos naturalmente parasitados. A atividade anti-helmíntica da associação foi avaliada em 12 animais necropsiados, os quais eram portadores de nematodioses gastrintestinais (infecção natural). Para determinação de remanescentes residuais em tecidos dos bovinos medicados foram necropsiados 26 animais. Nenhuma alteração significativa (P≥0,05) foi verificada nos parâmetros hematológicos (hemogramas) e bioquímicos mensurados nos bovinos medicados com nova associação, até o 10º dia pós-tratamento. A eficácia anti-ixodídica da associação fluazuron 3,0% + abamectina 0,5%* (stall test) atingiu índices de eficácia superiores a 80,00% em 78 datas experimentais. O fluazuron 2,5%** atingiu eficácia acima de 80,00% em 77 datas. Eficácia máxima (100,00%) foi atingida em 40 datas experimentais pela associação fluazuron 3,0% + abamectina 0,5%, enquanto que o fluazuron 2,5%** atingiu este índice em 51 datas. Estatisticamente as formulações fluazuron 3,0% + abamectina 0,5%* e fluazuron 2,5%** reduziram significativamente (P<0,05) as contagens de fêmeas de R. (B.) microplus (desprendidas), em relação ao grupo controle...
A novel drug formulation containing fluazuron 3,0% + abamectin 0,5%* administered via topical pour-on (1ml\10kg body weight) was evaluated in seven experiments, including clinical safety and pharmacokinetics of waste, these compounds in cattle treated. The clinical safety and security of the above formulation were assessed by clinical examination, blood counts and biochemical measurements. As for anti-tick activity, two tests were conducted, using an experimentally infected cattle and other cattle naturally infested by Rhipicephalus (Boophilus) microplus. In two other studies evaluated the efficacy against Haematobia irritans, against larvae of Dermatobia hominis in cattle naturally infected. The anthelmintic activity of the association was evaluated in 12 animals necropsied, who suffered from gastrointestinal nematodiosis (natural infection). To determine the remaining waste in tissues of cattle treated 26 animals were autopsied. No significant change (P ≥ 0.05) was observed in blood parameters (blood counts) and biochemical measured in cattle treated with the new association, until the 10th day post-treatment. The effectiveness of combination anti-ticks fluazuron 3.0% + abamectin 0.5%* (Stall test) reached peak levels of efficiency exceeding 80.00% in 78 experimental days. The fluazuron 2.5%** reached efficiency above 80.00% in 77 dates. Maximum efficiency (100.00%) was achieved in 40 experimental days by the pool fluazuron 3.0% + abamectin 0.5%*, while the fluazuron 2.5%** this index reached in 51 dates. Statistically formulations fluazuron 3.0% + abamectin 0.5%* and fluazuron 2.5%** significantly reduced (P <0.05) scores of female R. (B.) microplus (detached) in the control group, the 5th to 100th DPT and 14th to 100th DPT, respectively. In cattle naturally infected by R (B) microplus, the association fluazuron 3.0% + abamectin 0.5%* and fluazuron 2,5%** efficiency reached over... (Complete abstract click electronic access below)
A novel drug formulation containing fluazuron 3,0% + abamectin 0,5%* administered via topical pour-on (1ml\10kg body weight) was evaluated in seven experiments, including clinical safety and pharmacokinetics of waste, these compounds in cattle treated. The clinical safety and security of the above formulation were assessed by clinical examination, blood counts and biochemical measurements. As for anti-tick activity, two tests were conducted, using an experimentally infected cattle and other cattle naturally infested by Rhipicephalus (Boophilus) microplus. In two other studies evaluated the efficacy against Haematobia irritans, against larvae of Dermatobia hominis in cattle naturally infected. The anthelmintic activity of the association was evaluated in 12 animals necropsied, who suffered from gastrointestinal nematodiosis (natural infection). To determine the remaining waste in tissues of cattle treated 26 animals were autopsied. No significant change (P ≥ 0.05) was observed in blood parameters (blood counts) and biochemical measured in cattle treated with the new association, until the 10th day post-treatment. The effectiveness of combination anti-ticks fluazuron 3.0% + abamectin 0.5%* (Stall test) reached peak levels of efficiency exceeding 80.00% in 78 experimental days. The fluazuron 2.5%** reached efficiency above 80.00% in 77 dates. Maximum efficiency (100.00%) was achieved in 40 experimental days by the pool fluazuron 3.0% + abamectin 0.5%*, while the fluazuron 2.5%** this index reached in 51 dates. Statistically formulations fluazuron 3.0% + abamectin 0.5%* and fluazuron 2.5%** significantly reduced (P <0.05) scores of female R. (B.) microplus (detached) in the control group, the 5th to 100th DPT and 14th to 100th DPT, respectively. In cattle naturally infected by R (B) microplus, the association fluazuron 3.0% + abamectin 0.5%* and fluazuron 2,5%** efficiency reached over... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Bovino - Parasito, Endectocida, Fluazuron, Abamectina, Endectocide, Parasites, Cattle, Fluazuron, Abamectin
Como citar
MENDONÇA, Rafael Paranhos de. Atividade endectocida, segurança clínica e farmacocinética de resíduos de uma nova alternativa terapêutica (Fluazuron + Abamectina) em bovinos. 2010. vii, 167 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, 2010.