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dc.contributor.authorTeixeira Neto, Francisco José [UNESP]
dc.contributor.authorMcDonell, W. N.
dc.contributor.authorBlack, W. D.
dc.contributor.authorDuronghphongtorn, S.
dc.date.accessioned2014-05-20T13:31:53Z
dc.date.available2014-05-20T13:31:53Z
dc.date.issued2004-04-01
dc.identifierhttp://dx.doi.org/10.2460/ajvr.2004.65.456
dc.identifier.citationAmerican Journal of Veterinary Research. Schaumburg: Amer Veterinary Medical Assoc, v. 65, n. 4, p. 456-463, 2004.
dc.identifier.issn0002-9645
dc.identifier.urihttp://hdl.handle.net/11449/10870
dc.description.abstractObjective-To evaluate cardiopulmonary effects of glycopyrrolate in horses anesthetized with halothane and xylazine.Animals-6 horses.Procedure-Horses were allocated to 2 treatment groups in a randomized complete block design. Anesthesia was maintained in mechanically ventilated horses by administration of halothane (1% end-tidal concentration) combined with a constant-rate infusion of xylazine hydrochloride (1 mg/kg/h, IV). Hemodynamic variables were monitored after induction of anesthesia and for 120 minutes after administration of glycopyrrolate or saline (0.9% NaCl) solution. Glycopyrrolate (2.5 mug/kg, IV) was administered at 10-minute intervals until heart rate (HR) increased at least 30% above baseline or a maximum cumulative dose of 75 mug/kg had been injected. Recovery characteristics and intestinal auscultation scores were evaluated for 24 hours after the end of anesthesia.Results-Cumulative dose of glycopyrrolate administered to 5 horses was 5 mug/kg, whereas 1 horse received 75 mug/kg. The positive chronotropic effects of glycopyrrolate were accompanied by an increase in cardiac output, arterial blood pressure, and tissue oxygen delivery. Whereas HR increased by 53% above baseline values at 20 minutes after the last glycopyrrolate injection, cardiac output and mean arterial pressure increased by 38% and 31%, respectively. Glycopyrrolate administration was associated with impaction of the large colon in I horse and low intestinal auscultation scores lasting 24 hours in 3 horses.Conclusions and Clinical Relevance-The positive chronotropic effects of glycopyrrolate resulted in improvement of hemodynamic function in horses anesthetized with halothane and xylazine. However, prolonged intestinal stasis and colic may limit its use during anesthesia.en
dc.format.extent456-463
dc.language.isoeng
dc.publisherAmer Veterinary Medical Assoc
dc.relation.ispartofAmerican Journal of Veterinary Research
dc.sourceWeb of Science
dc.titleEffects of glycopyrrolate on cardiorespiratory function in horses anesthetized with halothane and xylazineen
dc.typeArtigo
dcterms.licensehttps://www.avma.org/News/Journals/Pages/journals-reprints.aspx
dcterms.rightsHolderAmer Veterinary Medical Assoc
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Guelph
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med Vet & Zootecn, Dept Vet Surg & Anesthesiol, BR-14870000 Botucatu, SP, Brazil
dc.description.affiliationUniv Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON N1G 2W1, Canada
dc.description.affiliationUniv Guelph, Ontario Vet Coll, Dept Clin Studies, Guelph, ON N1G 2W1, Canada
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med Vet & Zootecn, Dept Vet Surg & Anesthesiol, BR-14870000 Botucatu, SP, Brazil
dc.identifier.doi10.2460/ajvr.2004.65.456
dc.identifier.wosWOS:000220367200013
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.author.orcid0000-0002-3002-8093[1]
dc.relation.ispartofjcr0.833
dc.relation.ispartofsjr0,567
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