Synthesis and antimycobacterial activity of new pyrazolate-bridged dinuclear complexes of the type [Pd(mu-L)(N-3)(PPh3)](2) (PPh3 = triphenylphosphine; L = pyrazolates)
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Data
2014-10-01
Autores
Silva, C. da [UNESP]
Ferreira, J. G. [UNESP]
Mauro, A. E. [UNESP]
Frem, R. C. G. [UNESP]
Santos, R. H. A.
Silva, P. B. da [UNESP]
Pavan, Fernando Rogério [UNESP]
Marino, L. B. [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
Netto, A. V. G. [UNESP]
Título da Revista
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Título de Volume
Editor
Elsevier B.V.
Resumo
Binuclear compounds of the type [Pd(mu-L)(N-3)(PPh3)](2) {L = pyrazolate (1); 3,5-dimethylpyrazolate (2); 4-iodopyrazolate (3); PPh3 = triphenylphosphine} were synthesized and characterized by elemental analyses, infrared and H-1 and P-31{H-1} NMR spectroscopies. The crystal and molecular structures of the complex [Pd(mu-dmPz)(N-3)(PPh3)](2) (2) were determined by single-crystal X-ray diffraction techniques. In vitro antimycobacterial evaluation demonstrated that compound [Pd(mu-Pz)(N-3)(PPh3)](2) (1) displayed a MIC of 8.16 mu M, being more active than some commonly used anti-TB drugs and other Pd(II) complexes. (C) 2014 Elsevier B.V. All rights reserved.
Descrição
Palavras-chave
Binuclear Pd(II) compounds, Triphenylphosphine, Pyrazolates, Mycobacterium tuberculosis
Como citar
Inorganic Chemistry Communications. Amsterdam: Elsevier Science Bv, v. 48, p. 153-155, 2014.